摘要
背景:帕金森病(帕金森病)的发病机制尚未完全了解。在中枢神经系统中,因其氧化还原状态的不同,一氧化氮(NO)可以兼有保护和神经毒性作用。研究表明,NO的干预会导致一些神经系统疾病,如帕金森病等神经退行性疾病。目的:本文旨在于研究可能参与NO在帕金森病的发病机制。我们对有关PD患者和帕金森动物模型的病理、生化和遗传研究,以及有关NO在这些模型中的作用的文献进行归纳总结。结果:在PD患者和帕金森动物模型中,NO都能导致兴奋性毒性、炎症、氧化应激、线粒体功能损伤,DNA损伤,以及多种蛋白质的S-亚硝基化。
关键词: 一氧化氮、一氧化氮合酶、帕金森病、神经退行性疾病、氧化应激、兴奋性毒性、炎症、亚硝基化
Current Medicinal Chemistry
Title:An Update on the Role of Nitric Oxide in the Neurodegenerative Processes of Parkinson's Disease
Volume: 23 Issue: 24
Author(s): Félix Javier Jiménez-Jiménez, Hortensia Alonso-Navarro, María Trinidad Herrero, Elena García-Martín, José A.G. Agúndez
Affiliation:
关键词: 一氧化氮、一氧化氮合酶、帕金森病、神经退行性疾病、氧化应激、兴奋性毒性、炎症、亚硝基化
摘要: Background: The pathogenesis of Parkinson’s disease (PD) is not fully understood. Together with some important physiological functions in the Central Nervous System (CNS), nitric oxide (NO) can have both, neuroprotective or neurotoxic actions, depending on its redox state. An important body of evidence suggests the involvement of NO in many of the processes leading to neurodegeneration in several neurological disorders including PD. Objective: The main aim of this review is to update the data regarding the possible involvement of NO in the pathogenesis of PD. Methods: We performed a literature review on neuropathological, biochemical and genetic studies in PD patients and in several experimental models of parkinsonism and role of NO in these models. Results: Both studies in humans and in experimental models of parkinsonism give support to the contribution of NO in excitotoxicity, inflammation, oxidative stress, mitochondrial function impairment, DNA damage, and Snitrosylation of diverse proteins. The interaction of these mechanisms leads finally to neuronal death. The fact that selective of specific inhibitors of NO synthase (NOS, the enzyme responsible of NO synthesis) should prevent neuronal death through their actions of these pathogenic mechanisms supports the role of NO on PD as well. Conclusion: NO participates in the pathogenesis of PD by multiple mechanisms described in this review.
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Félix Javier Jiménez-Jiménez, Hortensia Alonso-Navarro, María Trinidad Herrero, Elena García-Martín, José A.G. Agúndez , An Update on the Role of Nitric Oxide in the Neurodegenerative Processes of Parkinson's Disease, Current Medicinal Chemistry 2016; 23 (24) . https://dx.doi.org/10.2174/0929867323666160812151356
DOI https://dx.doi.org/10.2174/0929867323666160812151356 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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