摘要
细胞色素P450药物代谢酶多态性高,表明个体对不同药物反应的差异性,这种差异也与种族有关。本研究的目的是总结现有的与罗马人细胞色素酶进行遗传多态性有关的数据。我们的目标是比较罗马人与其它人群等位基因变异的频率,基因型和预测的表型与相应的速率。本文系统地回顾了与罗马人细胞色素P450基因变异频率相关的文献。本研究研究的文献来源于网站和数据库,包括PubMed,Ensembl,dbSNP,HapMap 和1000 Genomes Project。本文试图总结和讨论目前的研究罗马人9个细胞色素基因(CYP1A2, CYP1B1, CYP2B6, CYP2C9, CYP2C19, CYP2C8, CYP2D6, CYP3A5, CYP4F2)的20个等位基因变异体的频率分布。罗马和匈牙利的样本之间具有7个不同的基因型的差异。CYP2C9 * 2 / * 3和CYP2C19 * 2 / * 2基因型均超过3倍的不同,此外,罗马人样品中7个变种等位基因(rs762551, rs3745274, rs1058930, rs1065852, rs3892097, rs1057910 and rs4244285)的频率也不同。不同民族间药物代谢酶的遗传多态性的不同,这也许可以解释不同的药物反应,也强调了药理学研究参与者的祖先的必要性。
关键词: 多态性,药理学,Roma、匈牙利、吉普赛、种族、细胞色素P450。
Current Medicinal Chemistry
Title:Cytochrome P450 Drug Metabolizing Enzymes in Roma Population Samples: Systematic Review of the Literature
Volume: 23 Issue: 31
Author(s): Renata Szalai, Kinga Hadzsiev, Bela Melegh
Affiliation:
关键词: 多态性,药理学,Roma、匈牙利、吉普赛、种族、细胞色素P450。
摘要: The cytochrome P450 drug metabolizing enzymes are highly polymorphic and show inter-individual differences in variability in drug response, which varies widely also with ethnicity. This study aims to summarize the available data on genetic polymorphisms associated with cytochrome enzymes conducted on Roma populations. Our goal was to compare the frequency of the variant alleles, genotypes and predicted phenotypes with corresponding rates from other populations. We carried out a systematic review including the papers published on the pharmacogenetically relevant variants of cytochrome P450 genes related to Roma population. The study was performed using several articles, websites and databases, including PubMed, Ensembl, dbSNP, HapMap and 1000 Genomes Project. This review attempts to summarize and discuss our current knowledge about the frequency distribution of the ever investigated 20 allelic variants of 9 cytochrome genes (CYP1A2, CYP1B1, CYP2B6, CYP2C9, CYP2C19, CYP2C8, CYP2D6, CYP3A5, CYP4F2) in Roma DNA samples and compare them with other populations. Differences between Roma and Hungarian samples are reported for 7 variant genotypes. CYP2C9 *2/*3 and CYP2C19 *2/*2 genotypes showed more than 3-fold differences. Additional differences are displayed for allele frequency of 7 variants (rs762551, rs3745274, rs1058930, rs1065852, rs3892097, rs1057910 and rs4244285) in Roma population samples. The interethnic variability in clinically relevant genetic polymorphisms of drug metabolizing enzymes, which may explain distinct drug response, highlights the need to allow for the ancestry of participants in pharmacogenetic studies.
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Cite this article as:
Renata Szalai, Kinga Hadzsiev, Bela Melegh , Cytochrome P450 Drug Metabolizing Enzymes in Roma Population Samples: Systematic Review of the Literature, Current Medicinal Chemistry 2016; 23 (31) . https://dx.doi.org/10.2174/0929867323666160809092455
DOI https://dx.doi.org/10.2174/0929867323666160809092455 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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