摘要
细胞色素P450药物代谢酶多态性高,表明个体对不同药物反应的差异性,这种差异也与种族有关。本研究的目的是总结现有的与罗马人细胞色素酶进行遗传多态性有关的数据。我们的目标是比较罗马人与其它人群等位基因变异的频率,基因型和预测的表型与相应的速率。本文系统地回顾了与罗马人细胞色素P450基因变异频率相关的文献。本研究研究的文献来源于网站和数据库,包括PubMed,Ensembl,dbSNP,HapMap 和1000 Genomes Project。本文试图总结和讨论目前的研究罗马人9个细胞色素基因(CYP1A2, CYP1B1, CYP2B6, CYP2C9, CYP2C19, CYP2C8, CYP2D6, CYP3A5, CYP4F2)的20个等位基因变异体的频率分布。罗马和匈牙利的样本之间具有7个不同的基因型的差异。CYP2C9 * 2 / * 3和CYP2C19 * 2 / * 2基因型均超过3倍的不同,此外,罗马人样品中7个变种等位基因(rs762551, rs3745274, rs1058930, rs1065852, rs3892097, rs1057910 and rs4244285)的频率也不同。不同民族间药物代谢酶的遗传多态性的不同,这也许可以解释不同的药物反应,也强调了药理学研究参与者的祖先的必要性。
关键词: 多态性,药理学,Roma、匈牙利、吉普赛、种族、细胞色素P450。
Current Medicinal Chemistry
Title:Cytochrome P450 Drug Metabolizing Enzymes in Roma Population Samples: Systematic Review of the Literature
Volume: 23 Issue: 31
Author(s): Renata Szalai, Kinga Hadzsiev, Bela Melegh
Affiliation:
关键词: 多态性,药理学,Roma、匈牙利、吉普赛、种族、细胞色素P450。
摘要: The cytochrome P450 drug metabolizing enzymes are highly polymorphic and show inter-individual differences in variability in drug response, which varies widely also with ethnicity. This study aims to summarize the available data on genetic polymorphisms associated with cytochrome enzymes conducted on Roma populations. Our goal was to compare the frequency of the variant alleles, genotypes and predicted phenotypes with corresponding rates from other populations. We carried out a systematic review including the papers published on the pharmacogenetically relevant variants of cytochrome P450 genes related to Roma population. The study was performed using several articles, websites and databases, including PubMed, Ensembl, dbSNP, HapMap and 1000 Genomes Project. This review attempts to summarize and discuss our current knowledge about the frequency distribution of the ever investigated 20 allelic variants of 9 cytochrome genes (CYP1A2, CYP1B1, CYP2B6, CYP2C9, CYP2C19, CYP2C8, CYP2D6, CYP3A5, CYP4F2) in Roma DNA samples and compare them with other populations. Differences between Roma and Hungarian samples are reported for 7 variant genotypes. CYP2C9 *2/*3 and CYP2C19 *2/*2 genotypes showed more than 3-fold differences. Additional differences are displayed for allele frequency of 7 variants (rs762551, rs3745274, rs1058930, rs1065852, rs3892097, rs1057910 and rs4244285) in Roma population samples. The interethnic variability in clinically relevant genetic polymorphisms of drug metabolizing enzymes, which may explain distinct drug response, highlights the need to allow for the ancestry of participants in pharmacogenetic studies.
Export Options
About this article
Cite this article as:
Renata Szalai, Kinga Hadzsiev, Bela Melegh , Cytochrome P450 Drug Metabolizing Enzymes in Roma Population Samples: Systematic Review of the Literature, Current Medicinal Chemistry 2016; 23 (31) . https://dx.doi.org/10.2174/0929867323666160809092455
DOI https://dx.doi.org/10.2174/0929867323666160809092455 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Treatments for Hypertension in Type 2 Diabetes-Non-pharmacological and Pharmacological Measurements<sup>#</sup>
Current Hypertension Reviews Experimental Rodent Models of Vascular Dementia: A Systematic Review
CNS & Neurological Disorders - Drug Targets Cardioprotective Effects of the I<sub>f</sub> Current Inhibition by Ivabradine During Cardiac Dysfunction
Current Pharmaceutical Biotechnology Update on the Slow Delayed Rectifier Potassium Current (IKs): Role in Modulating Cardiac Function
Current Medicinal Chemistry Cardiometabolic Risk Related to the Association of hypertriglyceridemia-Low HDLc
Current Pharmaceutical Design Aliskiren in Patients with Diabetes: A Systematic Review
Current Vascular Pharmacology Cardiovascular-Related
Current Bioactive Compounds Current Status of Hormone Replacement Therapy in Post Menopausal Women
Current Drug Therapy Pharmacologic Targeting of Endothelial Progenitor Cells
Cardiovascular & Hematological Disorders-Drug Targets Treatment for Obsessive Compulsive Disorder
Current Psychiatry Reviews Recommendations for the Treatment of Hypertension in Elderly People
Cardiovascular & Hematological Agents in Medicinal Chemistry Application of Pharmacogenomic Approaches in the Study of Drug Response in Complex Diseases
Current Pharmacogenomics Mineralocorticoid Receptor Antagonism and Cardiac Remodeling in Ischemic Heart Failure
Current Medicinal Chemistry - Cardiovascular & Hematological Agents Dietary Technologies to Optimize Healing from Injury-Induced Inflammation
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry PGD and Prenatal Diagnosis: Comparison and Review in Different Genetic Disorders
Current Women`s Health Reviews Association of Zinc and Copper Status with Cardiovascular Diseases and their Assessment Methods: A Review Study
Mini-Reviews in Medicinal Chemistry Pharmacotherapy in Neonatal and Pediatric Extracorporeal Membrane Oxygenation (ECMO)
Current Drug Metabolism Gene-Activators Prevent and Regress Atherosclerosis and Reduce Mortality
Cardiovascular & Hematological Agents in Medicinal Chemistry Past, Present and Future of Nutrigenomics and its Influence on Drug Development
Current Drug Discovery Technologies Anti-VEGF Therapy for Retinal Vein Occlusions
Current Drug Targets