Abstract
DNA topoisomerases are important cellular enzymes found in almost all types of living cells (eukaryotic and prokaryotic). These enzymes are essential for various DNA metabolic processes e.g. replication, transcription, recombination, chromosomal decatenation etc. These enzymes are important molecular drug targets and inhibitors of these enzymes are widely used as effective anticancer and antibacterial drugs. However, topoisomerase inhibitors have some therapeutic limitations and they exert serious side effects during cancer chemotherapy. Thus, development of novel anticancer topoisomerase inhibitors is necessary for improving cancer chemotherapy. Nature serves as a repertoire of structurally and chemically diverse molecules and in the recent years many DNA topoisomerase inhibitors have been identified from natural sources. The present review discusses anticancer properties and therapeutic importance of eighteen recently identified natural topoisomerase inhibitors (from the year 2009 to 2015). Structural characteristics of these novel inhibitors provide backbones for designing and developing new anticancer drugs.
Keywords: DNA topoisomerases, Topoisomerase inhibitors, Anticancer agents, Natural products.
Graphical Abstract
Current Genomics
Title:Natural Compounds as Anticancer Agents Targeting DNA Topoisomerases
Volume: 18 Issue: 1
Author(s): Chetan Kumar Jain, Hemanta Kumar Majumder and Susanta Roychoudhury
Affiliation:
Keywords: DNA topoisomerases, Topoisomerase inhibitors, Anticancer agents, Natural products.
Abstract: DNA topoisomerases are important cellular enzymes found in almost all types of living cells (eukaryotic and prokaryotic). These enzymes are essential for various DNA metabolic processes e.g. replication, transcription, recombination, chromosomal decatenation etc. These enzymes are important molecular drug targets and inhibitors of these enzymes are widely used as effective anticancer and antibacterial drugs. However, topoisomerase inhibitors have some therapeutic limitations and they exert serious side effects during cancer chemotherapy. Thus, development of novel anticancer topoisomerase inhibitors is necessary for improving cancer chemotherapy. Nature serves as a repertoire of structurally and chemically diverse molecules and in the recent years many DNA topoisomerase inhibitors have been identified from natural sources. The present review discusses anticancer properties and therapeutic importance of eighteen recently identified natural topoisomerase inhibitors (from the year 2009 to 2015). Structural characteristics of these novel inhibitors provide backbones for designing and developing new anticancer drugs.
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Cite this article as:
Jain Kumar Chetan, Majumder Kumar Hemanta and Roychoudhury Susanta, Natural Compounds as Anticancer Agents Targeting DNA Topoisomerases, Current Genomics 2017; 18 (1) . https://dx.doi.org/10.2174/1389202917666160808125213
DOI https://dx.doi.org/10.2174/1389202917666160808125213 |
Print ISSN 1389-2029 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5488 |
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