TREM2 p.H157Y Variant and the Risk of Alzheimer’s Disease: A Meta-Analysis Involving 14,510 Subjects

Title:TREM2 p.H157Y Variant and the Risk of Alzheimer’s Disease: A Meta-Analysis Involving 14,510 Subjects

Volume: 13 Issue: 4

Author(s): Teng Jiang, Jian-Kang Hou, Qing Gao, Jin-Tai Yu, Jun-Shan Zhou, Hong-Dong Zhao and Ying-Dong Zhang

Affiliation:

Keywords: TREM2, Alzheimer’s disease, meta-analysis, p, H157Y, rs2234255, Variant.

Abstract: We recently revealed that p.H157Y (rs2234255), a rare coding variant of triggering receptor expressed on myeloid cells 2 gene (TREM2), was associated with Alzheimer’s disease (AD) susceptibility in Han Chinese. Contrastingly, although p.H157Y was previously identified in both AD cases and controls by several sequencing studies, no association of this variant with disease susceptibility was reported. To gain a credible conclusion on the association between p.H157Y and AD risk, a meta-analysis involving 7,102 cases and 7,408 controls was conducted. Our results indicated that p.H157Y was associated with an increased risk of AD (OR=3.65, 95% CI: 1.61-8.28; P=0.002), further establishing TREM2 as an important susceptibility gene for this disease.

Cite this article as:

Jiang Teng, Hou Jian-Kang, Gao Qing, Yu Jin-Tai, Zhou Jun-Shan, Zhao Hong-Dong and Zhang Ying-Dong, TREM2 p.H157Y Variant and the Risk of Alzheimer’s Disease: A Meta-Analysis Involving 14,510 Subjects, Current Neurovascular Research 2016; 13 (4) . https://dx.doi.org/10.2174/1567202613666160808095530