Allele Frequencies of CYP2D6, CYP3A5 and DPYD Genes Polymorphisms in the Healthy Yakut Population

Title:Allele Frequencies of CYP2D6, CYP3A5 and DPYD Genes Polymorphisms in the Healthy Yakut Population

Volume: 14 Issue: 1

Author(s): Filipp F. Vasilyev, Diana A. Danilova, Vladimir S. Kaimonov, Yana V. Chertovskih and Nadezda R. Maksimova

Affiliation:

Keywords: Allele frequency, genotyping, personalize medicine, pharmacogenetics, polymorphism, Yakuts.

Abstract: Background: It is known that the distribution of polymorphism frequencies can vary greatly between different ethnic groups, resulting in variable percentages of poor, intermediate or extensive metabolizers in a given population.

Objective: This study was carried out to estimate the genotype frequencies of common variants in the CYP2D6, CYP3A5 and DPYD genes in the Yakut population from North-Eastern Siberia. To compare the allelic distribution found with the frequencies reported for other ethnic groups.

Method: Genotyping was carried out by real-time polymerase-chain reaction in a total of 100 healthy unrelated Yakut subjects (CYP2D6 c.100C>T, CYP3A5 g.6986G>A, DPYD c.1905+1G>A, DPYD c.1679T>G, DPYD c.2846T>A).

Results: The allele frequencies for CYP3A5*3 and DPYD*13 in Yakuts were 0.08 and 0.01, respectively. No DPYD*2A and DPYD c.2846A alleles were detected.

Conclusion: Our data on the distribution of frequencies of genotypes and alleles of polymorphisms of CYP2D6, CYP3A5 and DPYD genes in the Yakut population as a whole are more characteristic of the European populations.

Cite this article as:

Vasilyev F. Filipp, Danilova A. Diana, Kaimonov S. Vladimir, Chertovskih V. Yana and Maksimova R. Nadezda, Allele Frequencies of CYP2D6, CYP3A5 and DPYD Genes Polymorphisms in the Healthy Yakut Population, Current Pharmacogenomics and Personalized Medicine 2016; 14 (1) . https://dx.doi.org/10.2174/1875692114666160801151257

DOI https://dx.doi.org/10.2174/1875692114666160801151257	Print ISSN 1875-6921
Publisher Name Bentham Science Publisher	Online ISSN 1875-6913