摘要
背景:最近的研究结果表明,精神病患者多巴胺异常在可能继发于一氧化氮功能障碍,一氧化氮还可能影响谷氨酸和多巴胺能神经传递,这些都与精神病有关。目的:对研究一氧化氮在精神病患者中的影响的相关研究进行归纳总结。方法:对PubMed和ISI Web of Science在线收藏文献进行检索。检索的关键词是“精神病性障碍和一氧化氮”,“精神病与一氧化氮”、“分裂型人格障碍和一氧化氮”、“妄想症和一氧化氮”、“短暂精神病性障碍和一氧化氮”、“分裂样精神障碍和一氧化氮”、“分裂情感障碍和一氧化氮”,和“精神分裂症与一氧化氮”。主要是近十年发表的英语文章。结果:最初,搜索共产生了95项研究结果,最终,我们选择了其中的39例。选定的文章被分为五组:生化研究组(n = 15;38.5%),遗传研究组(n = 11;28.2%),死后研究组(n = 6;15.4%),临床试验组(n = 6;15.4%)和病例报告(n = 1;2.5%)。多数的这些文章表明了一氧化氮的功能性障碍对精神病的影响。结论:研究结果表明一氧化氮是导致精神病的关键因素,同时,NO作为未来的药物干预的靶点值得深入研究。
关键词: 一氧化氮,一氧化氮系统、精神病、精神障碍、精神分裂症、分裂情感性障碍。
Current Medicinal Chemistry
Title:Nitric Oxide’s Involvement in the Spectrum of Psychotic Disorders
Volume: 23 Issue: 24
Author(s): João Paulo Maia-de-Oliveira, Ludmyla Kandratavicius, Emerson Arcoverde Nunes, João Paulo Machado-de-Sousa, Jaime E. Hallak and Serdar Murat Dursun
Affiliation:
关键词: 一氧化氮,一氧化氮系统、精神病、精神障碍、精神分裂症、分裂情感性障碍。
摘要: Background: Recent findings suggest that dopaminergic abnormalities found in psychotic disorders may be secondary to nitric oxide dysfunctions. Nitric oxide seems to influence glutamatergic and dopaminergic neurotransmission, both of which have been associated with psychosis. Objective: To search and review published works which examined the influence of nitric oxide in psychotic disorders subjects. Method: The research was executed in the on-line collections of Pubmed and ISI Web of Science. The key aspects utilized were “Psychotic Disorders AND Nitric Oxide”, “Psychosis AND Nitric Oxide”,“Schizotypal Personality Disorder AND Nitric Oxide”, “Delusional Disorder AND Nitric Oxide”, “Brief Psychotic Disorder AND Nitric Oxide”, “Schizophreniform Disorder AND Nitric Oxide”, “Schizoaffective Disorder AND Nitric Oxide”, and “Schizophrenia AND Nitric Oxide”. Empirical works utilizing human subjects, published in the last 10 years, in English language were included. Results: Initially, the search yielded a total of 95 studies. Then, 39 were elected according to the inclusion requirements. The selected articles were divided into five groups: biochemical studies (n=15; 38.5%), genetic studies (n=11; 28.2%), postmortem studies (n=6; 15.4%), clinical trials (n=6; 15.4%), and case reports (n=1; 2.5%). The studies evaluated only schizophrenic or schizoaffective disorder subjects. The great majority of them found evidence of nitric oxide dysfunctions in psychosis. Conclusion: The results of the review strengthen the idea that nitric oxide has a key participation in psychotic disorders and deserves deeper investigation as a target for future pharmacological intervention.
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João Paulo Maia-de-Oliveira, Ludmyla Kandratavicius, Emerson Arcoverde Nunes, João Paulo Machado-de-Sousa, Jaime E. Hallak and Serdar Murat Dursun , Nitric Oxide’s Involvement in the Spectrum of Psychotic Disorders, Current Medicinal Chemistry 2016; 23 (24) . https://dx.doi.org/10.2174/0929867323666160721144549
DOI https://dx.doi.org/10.2174/0929867323666160721144549 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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