胰岛素抵抗，内皮功能障碍和生活方式变化在糖尿病患者心血管疾病发展中的作用

Title:Roles of Insulin Resistance, Endothelial Dysfunction and Lifestyle Changes in the Development of Cardiovascular Disease in Diabetic Patients

Volume: 18 Issue: 15

关键词: 糖尿病（DM），心血管疾病，胰岛素抵抗，内皮，心血管危险，高血糖

摘要: Background: Diabetes mellitus (DM) caused 1.3 million deaths in 2010, and cardiovascular disease is the leading cause of mortality of diabetic patients. Cardiovascular disease in DM involves complex pathophysiology processes, which are promoted by many risk factors.

Objective: Genetic, epigenetic, lifestyle and environmental factors are responsible for the current epidemic of diabetes and the subsequent increased risk of cardiovascular disease. Over the past years, targets focusing on the increased risk of cardiovascular events in diabetic patients have attracted significant interest.

Conclusion: Within this review, the roles of insulin resistance, endothelial dysfunction and lifestyle changes in the development of cardiovascular disease in diabetic patients are discussed. Potential strategies and challenges in targeting cardiovascular risks in diabetic individuals are also considered.

Cite this article as:

Roles of Insulin Resistance, Endothelial Dysfunction and Lifestyle Changes in the Development of Cardiovascular Disease in Diabetic Patients, Current Drug Targets 2017; 18 (15) . https://dx.doi.org/10.2174/1389450117666160715145518