Abstract
Aim: The aim of the present investigation is to prepare mefenamic acid nano-particles by desolvation technique using ethanol and isopropanol as desolvating agents.
Methodology: To 1% aqueous solution of mefenamic acid the desolvating agent was added intermittently at the rate of 1 ml per every five minutes till the solution become turbid.Then a cross linking agent was added and kept for stirring for a period of 8 hours. Results: Two formulations F1 and F2 were prepared by using ethanol and isopropanol as desolvating agents respectively. The product yield, drug content, entrapment efficiency and loading capacity of F1 was found to be 67.9%, 73.7%, 70.85% and 49.6% respectively. The drug release was found to be 88.57% in a time period of 9hours. The product yield, drug content, entrapment efficiency and loading capacity of F2 was found to be 65%, 53.5%, 92.6% and 61.76% respectively. The drug release was sustained up to 10 hrs with a release rate of 71.47%. Conclusion: Based on the results F1 formulation was considered as the best formulation because of less particle size, greater stability, good entrapment efficiency and high release rate.Keywords: BSA, disolvating agent, mefenamic acid, particle size analyzer, SEM, TEM, Zeta potential.
Graphical Abstract
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