（R）-蓖麻酸衍生物的合成和生物活性：综述

Title:Synthesis and Bioactivity of (R)-Ricinoleic Acid Derivatives: A Review

Volume: 23 Issue: 35

Author(s): Sylwia Pabiś and Józef Kula

Affiliation:

关键词: 蓖麻油酸，蓖麻油衍生物，生物活性，抗菌活性抗肿瘤活性，蓖麻，聚酯，生物聚合物。

摘要: (R)-Ricinoleic acid (RA) [(12R,9Z)-hydroxyoctadecenoic acid], the main compound of castor seed oil, because of its unusual structure readily undergoes multi-directional chemical and biochemical transformations to produce derivatives with the retained carbon skeleton or with its degradation. Many of these are of high biological activity, as documented by an in vitro study, and possess therapeutic potential. This review article provides an overview of the recent developments in the area of synthesis of RA based compounds with anticancer and antimicrobial activities. Moreover, the antiinflammatory and analgesic properties of some ricinoleic acid derivatives are also highlighted.

Cite this article as:

Sylwia Pabiś and Józef Kula , Synthesis and Bioactivity of (R)-Ricinoleic Acid Derivatives: A Review, Current Medicinal Chemistry 2016; 23 (35) . https://dx.doi.org/10.2174/0929867323666160627104453