The Multiple Roles of XBP1 in Regulation of Glucose and Lipid Metabolism

Title:The Multiple Roles of XBP1 in Regulation of Glucose and Lipid Metabolism

Volume: 18 Issue: 6

Author(s): Jianjing Yang, Xiaojie Wu, Xiaoting Wu, Dijia Zhou, Tengmei Lin, Saidan Ding, Yu Zhang, Jiangnan Xue*Qichuan Zhuge*

Affiliation:

• Department of Immunology, Binzhou Medical University, Yantai,China

• Department of Neurosurgery, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000,China

Keywords: Metabolic regulator/housekeeper, XBP1, PI3K, ER stress, IRE1α, insulin.

Abstract: X-box binding protein1 (XBP1) especially exerts its fundamental effects in the cellular organelle endoplasmic reticulum (ER) via affecting three trans-membrane stress sensor proteins: PKRlike ER kinase (PERK), inositol-requiring enzyme 1(IRE1) and activating transcription factor 6(ATF6). At the center of XBP1’s broad effects is its remarkable metabolic housekeeper function. XBP1 decreased glucose dysfunction via funneling its effects on improving insulin sensitivity and stimulating insulin secretion. However, XBP1 also yields its double-edged effects, driving the transformation from excess glucose to lipid, which is a key contribution to obesity and T2DM. In this review, we highlight the vital mechanism of XBP1 in manipulating glucose and lipid metabolism involved by multiple signaling pathways.

Cite this article as:

Yang Jianjing, Wu Xiaojie, Wu Xiaoting, Zhou Dijia, Lin Tengmei, Ding Saidan, Zhang Yu, Xue Jiangnan*, Zhuge Qichuan*, The Multiple Roles of XBP1 in Regulation of Glucose and Lipid Metabolism, Current Protein & Peptide Science 2017; 18 (6) . https://dx.doi.org/10.2174/1389203717666160627085011