From Histones to RNA: Role of Methylation in Signal Proteins Involved in Adipogenesis

Title:From Histones to RNA: Role of Methylation in Signal Proteins Involved in Adipogenesis

Volume: 18 Issue: 6

Author(s): Xinxia Wang and Yizhen Wang*

Affiliation:

• College of Animal Sciences, Zhejiang University, Hangzhou, Zhejiang 310058,China

Keywords: Histone methylation, DNA methylation, RNA methylation, adipogenesis, methyltransferase, demethylase.

Abstract: New fat cells originate from a preexisting population of undifferentiated progenitor cells named preadipocytes. The process in which preadipocytes proliferate and differentiate into mature adipocytes under certain circumstances is called adipogenesis. In the past decade, many epigenetic factors have been shown to be pivotal for the appropriate timing of adipogenesis. A large number of coregulators at critical gene promoters set up specific patterns of DNA methylation, histone methylation and RNA methylation, which act as an epigenetic code to modulate the correct progress of adipocyte differentiation and adipogenesis. In this review, we focus on the functions and roles of epigenetic processes in preadipocyte differentiation and adipogenesis.

Cite this article as:

Wang Xinxia and Wang Yizhen*, From Histones to RNA: Role of Methylation in Signal Proteins Involved in Adipogenesis, Current Protein & Peptide Science 2017; 18 (6) . https://dx.doi.org/10.2174/1389203717666160627082444

DOI https://dx.doi.org/10.2174/1389203717666160627082444	Print ISSN 1389-2037
Publisher Name Bentham Science Publisher	Online ISSN 1875-5550