S-Nitrosothiols as Nitric Oxide-Donors: Chemistry, Biology and Possible Future Therapeutic Applications

Title: S-Nitrosothiols as Nitric Oxide-Donors: Chemistry, Biology and Possible Future Therapeutic Applications

Volume: 11 Issue: 20

Author(s): A. Ferro

Affiliation:

Keywords: nitric oxide, nitric oxide donors, s-nitrosothiols, therapeutics

Abstract: In recent years, the gaseous molecule nitric oxide (NO) has been shown to be involved in many important biological events. S-Nitrosothiols are biological substances derived endogenously from NO, and are found in a variety of tissues exhibiting NO-mimetic activity. Fundamental studies on the chemical aspects of S-nitrosothiols have become an integral part of NO research, with a view to further understanding the numerous biological functions both of NO and of S-nitrosothiols themselves. It has often been suggested that Snitrosothiols represent a means either for the storage or transport of NO, although the evidence for this is sparse. Many S-nitrosothiols have now been synthesized chemically, and at present they show the most promise as clinically useful NO-donor drugs. In this review, we examine in detail the biological functions of Snitrosothiols, as well as the chemical properties and biomedical applications of these compounds.

Cite this article as:

Ferro A., S-Nitrosothiols as Nitric Oxide-Donors: Chemistry, Biology and Possible Future Therapeutic Applications, Current Medicinal Chemistry 2004; 11 (20) . https://dx.doi.org/10.2174/0929867043364397