Microwave Assisted Synthesis and Antifungal Activity of Some Novel Thioethers Containing 1,2,4-triazolo[4,3-a] pyridine Moiety

Title:Microwave Assisted Synthesis and Antifungal Activity of Some Novel Thioethers Containing 1,2,4-triazolo[4,3-a] pyridine Moiety

Volume: 13 Issue: 6

Author(s): Zhi-Wen Zhai, Yan-Xia Shi, Ming-Yan Yang, Wen Zhao, Zhao-Hui Sun, Jian-Quan Weng, Cheng-Xia Tan, Xing-Hai Liu, Bao-Ju Li and Yong-Gang Zhang

Affiliation:

Keywords: 1, 2, 4-triazolo[4, 3-a]pyridine, antifungal activities, microwave assisted synthesis, thioether.

Abstract: A novel series of novel 1,2,4-triazolo[4,3-a]pyridines were designed and synthesized under microwave irradiation condition. The structures were identified by ¹H NMR, MS and elemental analysis, and the antifungal activities of them were evaluated at 100 ppm. It was found that some of the 1,2,4-triazolo[4,3-a]pyridines displayed good antifungal activity. Among them, compound 2e exhibited good antifungal activity against Stemphylium lycopersici (Enjoji) Yamamoto and Fusarium oxysporum. Sp. Cucumebrium.

Cite this article as:

Zhai Zhi-Wen, Shi Yan-Xia, Yang Ming-Yan, Zhao Wen, Sun Zhao-Hui, Weng Jian-Quan, Tan Cheng-Xia, Liu Xing-Hai, Li Bao-Ju and Zhang Yong-Gang, Microwave Assisted Synthesis and Antifungal Activity of Some Novel Thioethers Containing 1,2,4-triazolo[4,3-a] pyridine Moiety, Letters in Drug Design & Discovery 2016; 13 (6) . https://dx.doi.org/10.2174/157018081306160618181757