摘要
背景:生发性基质出血是早产儿死亡和发病的主要原因。 这个脑区在早产的前72小时内容易出血和再出血。 血液制品的脑室扩张有助于脑损伤的机制。 后果包括终生脑积水,脑性麻痹和智力障碍。 不幸的是,很少有关于这个患者群体的治疗需求。 目的:本综述讨论了生发性基质出血,使用的动物模型和潜在的治疗靶点的机制。 结论:临床前研究中确定的潜在治疗方法包括皮质类固醇治疗,铁螯合剂给药和转化生长因子-β途径调节,这些都需要进一步的调查。 因此,在临床考虑之前,有效的临床前建模对于阐明和评估新的治疗方法至关重要。
关键词: 动物模型,药物发现,实验性脑积水,神经功能障碍,翻译研究。
图形摘要
Current Drug Targets
Title:Aligning Animal Models of Clinical Germinal Matrix Hemorrhage, From Basic Correlation to Therapeutic Approach
Volume: 18 Issue: 12
关键词: 动物模型,药物发现,实验性脑积水,神经功能障碍,翻译研究。
摘要: Background: Germinal matrix hemorrhage is a leading cause of mortality and morbidity from prematurity. This brain region is vulnerable to bleeding and re-bleeding within the first 72 hours of preterm life. Cerebroventricular expansion of blood products contributes to the mechanisms of brain injury. Consequences include lifelong hydrocephalus, cerebral palsy, and intellectual disability. Unfortunately little is known about the therapeutic needs of this patient population.
Objectives: This review discusses the mechanisms of germinal matrix hemorrhage, the animal models utilized, and the potential therapeutic targets. Conclusion: Potential therapeutic approaches identified in pre-clinical investigations include corticosteroid therapy, iron chelator administration, and transforming growth factor-β pathway modulation, which all warrant further investigation. Thus, effective preclinical modeling is essential for elucidating and evaluating novel therapeutic approaches, ahead of clinical consideration.Export Options
About this article
Cite this article as:
Aligning Animal Models of Clinical Germinal Matrix Hemorrhage, From Basic Correlation to Therapeutic Approach, Current Drug Targets 2017; 18 (12) . https://dx.doi.org/10.2174/1389450117666160615100538
DOI https://dx.doi.org/10.2174/1389450117666160615100538 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
Related Journals
Related Books
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Conventional (Continuous) EEG Monitoring in the NICU
Current Pediatric Reviews Relationship Between Oxidative Stress, Tau Level and Antioxidant Mechanisms of the KEAP-1/NRF-2/HO-1 in Children with Hydrocephalus
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry Functional Role of Lipoprotein Receptors in Alzheimers Disease
Current Alzheimer Research Ribosome Inactivating Proteins (RIPs) from Momordica charantia for Anti Viral Therapy
Current Molecular Medicine Clinical Applications of Transcranial Doppler Sonography
Reviews on Recent Clinical Trials The Importance of NAD in Multiple Sclerosis
Current Pharmaceutical Design Imaging and Clinical Features of Neurocutaneous Melanosis in the Pediatric Population
Current Medical Imaging Blood-Brain Barrier ABC-transporter P-glycoprotein in Alzheimer's Disease: Still a Suspect?
Current Pharmaceutical Design Pharmacological Treatment of Mild Cognitive Impairment as a Prodromal Syndrome of Alzheimer´s Disease
Current Neuropharmacology Muscular Dystrophies: Histology, Immunohistochemistry, Molecular Genetics and Management
Current Pharmaceutical Design Gender Differences in Characteristics and Outcome in Primary Intraventricular Hemorrhage
Current Neurovascular Research Diagnostic Accuracy of Sagittal TSE-T2W, Variable Flip Angle 3D TSET2W and High-resolution 3D Heavily T2W Sequences for the Stenosis of Two Localizations: The Cerebral Aqueduct and the Superior Medullary Velum
Current Medical Imaging A Role for TGF-β Signaling in Neurodegeneration: Evidence from Genetically Engineered Models
Current Alzheimer Research Post Dural Puncture Headache and Hypertension
Current Hypertension Reviews Suicide Gene Therapy Mediated by the Herpes Simplex Virus Thymidine Kinase Gene / Ganciclovir System: Fifteen Years of Application
Current Gene Therapy Caring for Children with Medical Complexity: Definitions, Challenges and Solutions
Current Pediatric Reviews Proteomic Analysis of Alzheimers Disease Cerebrospinal Fluid from Neuropathologically Diagnosed Subjects
Current Alzheimer Research Cognitive Impairment in Depression
Current Psychiatry Reviews Transthyretin Decrease in Plasma of MCI and AD Patients: Investigation of Mechanisms for Disease Modulation
Current Alzheimer Research FDG PET/MR Imaging in Major Neurocognitive Disorders
Current Alzheimer Research