对照临床生发性基质出血的动物模型，从基本相关到治疗方法

Title:Aligning Animal Models of Clinical Germinal Matrix Hemorrhage, From Basic Correlation to Therapeutic Approach

Volume: 18 Issue: 12

关键词: 动物模型，药物发现，实验性脑积水，神经功能障碍，翻译研究。

摘要: Background: Germinal matrix hemorrhage is a leading cause of mortality and morbidity from prematurity. This brain region is vulnerable to bleeding and re-bleeding within the first 72 hours of preterm life. Cerebroventricular expansion of blood products contributes to the mechanisms of brain injury. Consequences include lifelong hydrocephalus, cerebral palsy, and intellectual disability. Unfortunately little is known about the therapeutic needs of this patient population.

Objectives: This review discusses the mechanisms of germinal matrix hemorrhage, the animal models utilized, and the potential therapeutic targets.

Conclusion: Potential therapeutic approaches identified in pre-clinical investigations include corticosteroid therapy, iron chelator administration, and transforming growth factor-β pathway modulation, which all warrant further investigation. Thus, effective preclinical modeling is essential for elucidating and evaluating novel therapeutic approaches, ahead of clinical consideration.

Cite this article as:

Aligning Animal Models of Clinical Germinal Matrix Hemorrhage, From Basic Correlation to Therapeutic Approach, Current Drug Targets 2017; 18 (12) . https://dx.doi.org/10.2174/1389450117666160615100538

DOI https://dx.doi.org/10.2174/1389450117666160615100538	Print ISSN 1389-4501
Publisher Name Bentham Science Publisher	Online ISSN 1873-5592