摘要
背景:前列腺癌(PC)是前列腺细胞癌,是发达国家男性癌症死亡的首要原因,代表成年男性最常见的恶性肿瘤。实现活性药物和有希望的药物(包括蛋白质和肽)和核酸用于前列腺癌的可行治疗效果的关键障碍是靶向药物递送至前列腺癌细胞的稀缺性。因此,需要用于增强用于前列腺癌的活性剂的分类的新系统,策略或治疗方法成为重要的标准。目前,癌症研究重点是使用化疗药物的各种新型药物递送系统改善前列腺癌的治疗。这些新的药物递送系统包括纳米颗粒和脂质体。此外,针对前列腺癌的策略或治疗方法包括用于局部前列腺癌的放射治疗,用于抑制肿瘤生长的激素治疗以及基因和免疫治疗。这些系统和方法可以将药物递送到其选择的或靶向的癌细胞中,用于在前列腺癌的气氛中的药物释放,从而增强肿瘤穿透的有效性。 目标:目的是收集和报告最近的研究结果来管理个人电脑。现在的审查包括现有的多样化的新型药物递送系统和旨在管理PC的方法。 结论:报告的杂项新型药物递送系统以及各种疗法似乎是精确,安全和相对有效的;因此可能导致前列腺癌闭塞的新轨迹。
关键词: 前列腺癌,输送系统,近距离放射治疗,睾丸切除术,基因治疗,药物靶标。
图形摘要
Current Drug Targets
Title:Current Perspectives on Novel Drug Delivery Systems and Therapies for Management of Prostate Cancer: An Inclusive Review
Volume: 18 Issue: 11
关键词: 前列腺癌,输送系统,近距离放射治疗,睾丸切除术,基因治疗,药物靶标。
摘要: Background: Prostate cancer (PC) is a prostate gland cells carcinoma, the foremost reason of cancer deaths in men in developed countries, representing most common malignancy in adult males. The key obstacle to achieve practicable therapeutic effect of active drugs and capable hopeful agents including proteins and peptides, and nucleic acid for prostate cancer is the scarcity of targeted drug delivery to cells of prostate cancer. As a result, need for novel systems, strategies or therapeutic approaches to enhance the assortment of active agents meant for prostate cancer becomes an important criterion. Currently cancer research focuses on improving treatment of prostate cancer using various novel drug delivery systems of chemotherapeutic agents. These novel drug delivery systems comprise nanoparticles and liposomes. Also, strategies or therapeutic approaches intended for the prostate cancer include radiation therapy for localized prostate cancer, hormonal therapy for suppressing tumor growth, and gene-and-immunologic therapy. These systems and approaches can deliver the drugs to their selected or targeted cancer cells for the drug release in cancer atmosphere of prostate thereby enhancing the effectiveness of tumor penetration.
Objective: The objective was to collect and report the recent research findings to manage the PC. Present review encloses existing diverse novel drug delivery systems and approaches intended for the management of PC. Conclusion: The reported miscellaneous novel drug delivery systems along with the diverse therapies are seem to be precise, secure and relatively effective; and in consequence could lead to a new track for obliteration of prostate cancer.Export Options
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Cite this article as:
Current Perspectives on Novel Drug Delivery Systems and Therapies for Management of Prostate Cancer: An Inclusive Review, Current Drug Targets 2017; 18 (11) . https://dx.doi.org/10.2174/1389450117666160613103705
DOI https://dx.doi.org/10.2174/1389450117666160613103705 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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