Abstract
Background: The Present work describe the synthetic protocol of a new series of 2-(4-(2-(5- Ethylpyridin-2-yl)ethoxy)phenyl)-4-(4-substituted)-2,3-dihydrobenzo [b][1,4]thiazepine (5a-j) by the cyclization of chalcones (4a-j) with 2-amino thiophenol by microwave induced solvent free conditions as well as conventional approach.
Methods: The elemental analysis and spectral method (IR, 1H and 13C NMR) were characterized the structure of all synthesized compounds.
Result: These compounds were screened for antibacterial and antifungal activity. Bezothiazepine derivative 5f showed potency (MBC = 50 µg/ml) against gram negative P. aeruginosa and 5i displyed encouraging activity (MFC = 200 µg/ml) against A. niger and A. clavatus.
Conclusion: The solvent less non-conventional microwave induced synthesis of compound (5a-j) has been proven considerable advantageous over conventional methods.
Keywords: Antibacterial, antifungal, benzothiazepine, chalcone, microwave, solvent-free.
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