Abstract
This review discusses the biological and medicinal significance of one of the most important and interesting heterocyclic ring systems, the pyrimidine and its condensed derivatives. Herein, various physiologically important molecules, as well as, therapeutically used drugs having a pyrimidine or condensed pyrimidine system in their chemical structures, have been covered. The chemistry and synthesis of pyrimidines have also been briefly discussed.
Keywords: Bioactive Heterocycles, Pyrimidines, Condensed Pyrimidines, Biological significance, Medicinal significance, Synthesis.
Graphical Abstract
Current Topics in Medicinal Chemistry
Title:The Chemistry and Bio-Medicinal Significance of Pyrimidines & Condensed Pyrimidines
Volume: 16 Issue: 28
Author(s): K. S. Jain, N. Arya, N. N. Inamdar, P. B. Auti, S. A. Unawane, H. H. Puranik, M. S. Sanap, A. D. Inamke, V. J. Mahale, C. S. Prajapati and C. J. Shishoo
Affiliation:
Keywords: Bioactive Heterocycles, Pyrimidines, Condensed Pyrimidines, Biological significance, Medicinal significance, Synthesis.
Abstract: This review discusses the biological and medicinal significance of one of the most important and interesting heterocyclic ring systems, the pyrimidine and its condensed derivatives. Herein, various physiologically important molecules, as well as, therapeutically used drugs having a pyrimidine or condensed pyrimidine system in their chemical structures, have been covered. The chemistry and synthesis of pyrimidines have also been briefly discussed.
Export Options
About this article
Cite this article as:
Jain S. K., Arya N., Inamdar N. N., Auti B. P., Unawane A. S., Puranik H. H., Sanap S. M., Inamke D. A., Mahale J. V., Prajapati S. C. and Shishoo J. C., The Chemistry and Bio-Medicinal Significance of Pyrimidines & Condensed Pyrimidines, Current Topics in Medicinal Chemistry 2016; 16 (28) . https://dx.doi.org/10.2174/1568026616666160609100410
DOI https://dx.doi.org/10.2174/1568026616666160609100410 |
Print ISSN 1568-0266 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4294 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Adenosine Receptor Ligands in Clinical Trials
Current Topics in Medicinal Chemistry Healing the Diabetic Heart: Modulation of Cardiometabolic Syndrome through Peroxisome Proliferator Activated Receptors (PPARs)
Current Molecular Pharmacology Therapeutic Potential of Endothelial Progenitor Cells for Cardiovascular Diseases
Current Vascular Pharmacology Cardiovascular and Renal Complications of Type 2 Diabetes in Obesity:Role of Sympathetic Nerve Activity and Insulin Resistance
Current Diabetes Reviews Annexin A5 Imaging: An Academic Research – Clinical Trials and Theses
Current Molecular Imaging (Discontinued) Catecholamines, Sympathetic Innervation and Immunity: Role in Experimental and Rheumatoid Arthritis
Letters in Drug Design & Discovery Involvement of the Transforming Growth Factor β in the Pathogenesis of Hereditary Hemorrhagic Telangiectasia
Current Pharmaceutical Design Indole-3-Carbinol (I3C) and its Major Derivatives: Their Pharmacokinetics and Important Roles in Hepatic Protection
Current Drug Metabolism Lycopene and Cardiovascular Diseases: An Update
Current Medicinal Chemistry HHT: A Rare Disease with A Broad Spectrum of Clinical Aspects
Current Pharmaceutical Design Co-expression Network Analysis Revealing the Potential Regulatory Roles of LncRNAs in Atrial Fibrillation
Current Bioinformatics Nutritional Status and Lipid Profile in HIV-Infected Adults
Endocrine, Metabolic & Immune Disorders - Drug Targets Cardiac Toxicity of Antineoplastic Anthracyclines
Current Medicinal Chemistry - Anti-Cancer Agents Sleep Apnea and Atrial Fibrillation; 2012 Update
Current Cardiology Reviews Diabetic CVD – Focus on Vitamin D
Cardiovascular & Hematological Agents in Medicinal Chemistry Safety Limits of Antidepressant Use Plus Combinations: Focus on Cardiovascular Function
Current Drug Metabolism Diabetic Heart and the Cardiovascular Surgeon
Cardiovascular & Hematological Disorders-Drug Targets Role of Antioxidants in Redox Regulation of Diabetic Cardiovascular Complications
Current Pharmaceutical Biotechnology Recent Patents on Anti-Cancer Potential of Helenalin
Recent Patents on Anti-Cancer Drug Discovery ATP-Sensitive Potassium Channel Modulators and Cardiac Arrhythmias: An Update
Current Pharmaceutical Design