Abstract
Oxidative stress and neuroinflammation cause many neurological disorders. Recently, it has been reported that molecular hydrogen (H2) functions as an antioxidant and anti-inflammatory agent. The routes of H2 administration in animal model and human clinical studies are roughly classified into three types, inhalation of H2 gas, drinking H2-dissolved water, and injection of H2-dissolved saline. This review discusses some of the remarkable progress that has been made in the research of H2 use for neurological disorders, such as cerebrovascular diseases, neurodegenerative disorders, and neonatal brain disorders. Although most neurological disorders are currently incurable, these studies suggest the clinical potential of H2 administration for their prevention, treatment, and mitigation. Several of the potential effectors of H2 will also be discussed, including cell signaling molecules and hormones that are responsible for preventing oxidative stress and inflammation. Nevertheless, further investigation will be required to determine the direct target molecule of H2.
Keywords: Brain injury, cerebrovascular disease, inflammation, molecular hydrogen, neonatal brain disorder, neurodegenerative disorder, oxidative stress.
Graphical Abstract
Current Neuropharmacology
Title:Molecular Hydrogen as a Neuroprotective Agent
Volume: 15 Issue: 2
Author(s): Masumi Iketani and Ikuroh Ohsawa
Affiliation:
Keywords: Brain injury, cerebrovascular disease, inflammation, molecular hydrogen, neonatal brain disorder, neurodegenerative disorder, oxidative stress.
Abstract: Oxidative stress and neuroinflammation cause many neurological disorders. Recently, it has been reported that molecular hydrogen (H2) functions as an antioxidant and anti-inflammatory agent. The routes of H2 administration in animal model and human clinical studies are roughly classified into three types, inhalation of H2 gas, drinking H2-dissolved water, and injection of H2-dissolved saline. This review discusses some of the remarkable progress that has been made in the research of H2 use for neurological disorders, such as cerebrovascular diseases, neurodegenerative disorders, and neonatal brain disorders. Although most neurological disorders are currently incurable, these studies suggest the clinical potential of H2 administration for their prevention, treatment, and mitigation. Several of the potential effectors of H2 will also be discussed, including cell signaling molecules and hormones that are responsible for preventing oxidative stress and inflammation. Nevertheless, further investigation will be required to determine the direct target molecule of H2.
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Cite this article as:
Iketani Masumi and Ohsawa Ikuroh, Molecular Hydrogen as a Neuroprotective Agent, Current Neuropharmacology 2017; 15 (2) . https://dx.doi.org/10.2174/1570159X14666160607205417
DOI https://dx.doi.org/10.2174/1570159X14666160607205417 |
Print ISSN 1570-159X |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6190 |
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