在动脉粥样硬化的细胞外基质：透明质酸和蛋白聚糖的见解

Title:Extracellular Matrix in Atherosclerosis: Hyaluronan and Proteoglycans Insights

Volume: 23 Issue: 26

Author(s): Manuela Viola, Evgenia Karousou, Maria Luisa D'Angelo, Paola Moretto, Ilaria Caon, Giancarlo De Luca, Alberto Passi and Davide Vigetti

Affiliation:

关键词: 透明质烷，动脉粥样硬化，血管内皮细胞，血管内膜，蛋白多糖。

摘要: Background: Atherosclerosis, a chronic inflammatory disease of the blood vessel wall, is the most common cause of cardiovascular pathologies. Hyaluronan, the major polysaccharide involved in this process, plays a pivotal role acting as a modulator of all inflammatory stages, affecting the behavior of both endothelial and smooth muscle cells.

Objective: The inflammatory condition is the main reason of the increased deposition of extracellular matrix, that in turn, traps lipoproteins and inflammatory/growth factors from the circulation within the vessel wall and thicken the arterial wall. Therefore, this chronic condition that continuously affects the arterial walls in a specific area causes a severe remodeling of the tissue architecture and a drastic change in the resident cell behavior.

Methods: Because of the great complexity of the extracellular matrix in the arterial wall, we investigate the modification in the different layers of the vessels with a particular attention to hyaluronan and proteoglycans and to the events that affects their normal turnover.

Results: Hyaluronan, the major polysaccharide involved in this process, plays a pivotal role acting as a modulator of all inflammatory stages, affecting the behavior of both endothelial and smooth muscle cells. Moreover, glycosaminoglycans and proteoglycans had been shown to change during the lesion progression, and to possess the chemical features essential for lipid retention, immune system activation, smooth cells proliferation and macrophages recruitment.

Conclusion: The ECM characteristics should be investigated in order to understand their prevention potentials as well as their negative impact on the onset of the disease.

Cite this article as:

Manuela Viola, Evgenia Karousou, Maria Luisa D'Angelo, Paola Moretto, Ilaria Caon, Giancarlo De Luca, Alberto Passi and Davide Vigetti , Extracellular Matrix in Atherosclerosis: Hyaluronan and Proteoglycans Insights, Current Medicinal Chemistry 2016; 23 (26) . https://dx.doi.org/10.2174/0929867323666160607104602