摘要
背景:克罗恩病(CD)是一种慢性,致残和破坏性疾病。一半患者会发生肠道损伤(狭窄,瘘管和/或脓肿)。目前的治疗策略未能改变其自然史。 目标:我们在一篇综述文章中探讨了从治疗强化的线性序列到集中于个性化患者护理的复杂算法超过四分之一个世纪的CD治疗的演变。具体而言,我们将重点放在评估疾病严重程度,选择严格的治疗目标,开始有效的治疗疗法以及管理继发性应答损失等不断发展的概念上。 结果:严格监测炎症的客观体征和治疗至靶向的方法可能是改变患者生命和疾病过程的唯一方法。我们现在试图根据患者概况,疾病表型和随后发生的独特药效动力学优化我们的治疗工具。 结论:用最新的治疗算法标准化胃肠专科医生的临床实践可能会最大限度地减少疾病相关并发症,同时有利于患者的生活质量。
关键词: 克罗恩病,治疗目标,抗肿瘤,治疗算法,药物监测,粘膜愈合。
图形摘要
Current Drug Targets
Title:Evolving Treatment Algorithms in Crohn's Disease
Volume: 19 Issue: 7
关键词: 克罗恩病,治疗目标,抗肿瘤,治疗算法,药物监测,粘膜愈合。
摘要: Background: Crohn's disease (CD) is a chronic, disabling and destructive condition. Half of patients will develop some bowel damage (stricture, fistula and/or abscess). Current therapeutic strategies failed to alter its natural history.
Objective: We explore in a review article the evolution of CD treatment over a quarter of a century from a linear sequence of treatment intensification to a complex algorithm focused on individualized patient care by looking beyond symptoms. Specifically we focus on evolving concepts in assessing disease severity, selecting rigorous treatment end-targets, initiating an effective therapeutic therapy, and managing secondary loss of response.
Results: A tight monitoring of objective signs of inflammation and a treat-to-target approach are probably the only way to change patients' life and disease course. We now seek to optimize our therapeutic tools according to patient profile, disease phenotype and the unique pharmacodynamics that ensues.
Conclusion: Standardizing the clinical practice of gastroenteroogists with the most current treatment algorithm may minimize disease related complications while favouring patient’s quality of life.
Export Options
About this article
Cite this article as:
Evolving Treatment Algorithms in Crohn's Disease, Current Drug Targets 2018; 19 (7) . https://dx.doi.org/10.2174/1389450117666160607075557
DOI https://dx.doi.org/10.2174/1389450117666160607075557 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
Related Journals
Related Books
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Synergistic Approaches to Clinical Oncology Biomarker Discovery
Current Topics in Medicinal Chemistry Potential of DNMT and its Epigenetic Regulation for Lung Cancer Therapy
Current Genomics DNA Double Strand Break Repair - Related Synthetic Lethality
Current Medicinal Chemistry Artery of Percheron Infarction: A Characteristic Pattern of Ischemia and Variable Clinical Presentation: A Literature Review
Current Medical Imaging Medicinal Plants in Neurodegenerative Diseases: Perspective of Traditional Persian Medicine
Current Drug Metabolism Resveratrol and Neurodegenerative Diseases: Activation of SIRT1 as the Potential Pathway towards Neuroprotection
Current Neurovascular Research Targeting Hsp90 in Non-Cancerous Maladies
Current Topics in Medicinal Chemistry Bone Changes in Patients with Inflammatory Arthritis Treated with Biological Therapies: A Clinical Perspective
Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry (Discontinued) Mutation Analysis of ABL1 Gene and its Relation to the Achievement of Major Molecular Response in Indonesian Chronic Myeloid Leukemia Patients
Current Pharmacogenomics and Personalized Medicine The Impact of Thrombopoietin on Clinical Practice
Current Pharmaceutical Design Detecting Growing Mammary Tumors with Monoclonal Antibodies Against Vascular Endothelial Growth Factor Receptor – 3
Current Radiopharmaceuticals The CXCR4/SDF-1 Chemokine Axis: A Potential Therapeutic Target for Bone Metastases?
Current Pharmaceutical Design Platelet Ca2+ATPases: Identification and Regulation in Hypertension
Current Hypertension Reviews Integrins in Drug Targeting-RGD Templates in Toxins
Current Pharmaceutical Design Potentiation of Anti-Cancer Treatment by Modulators of Energy Metabolism
Current Pharmaceutical Biotechnology Polo-Like Kinases Inhibitors
Current Medicinal Chemistry Editorial [Hot Topic: Acute Hepatitis C: Epidemiology, Pathogenesis and Therapy (Executive Editor: Paolo Fabris) ]
Current Pharmaceutical Design Herpesvirus / Retrovirus Chimeric Vectors
Current Gene Therapy Antioxidant and Antiproliferative Activity of Selected Medicinal Plants of Lower Assam, India: An In Vitro and In Silico Study
Anti-Cancer Agents in Medicinal Chemistry Development of a Mimotope-Based Vaccine Against CD20 Antigen
Protein & Peptide Letters