摘要
目的:探讨酒精和在一组阿尔茨海默氏病(AD)患者的认知能力下降之间的关系,包括量和类型。 方法:在纽约,波士顿,巴尔的摩和巴黎的360例早期阿尔茨海默氏病患者进行随访,每半年一次到19.28年。在每次访问时,用改良迷你精神状态检查(mMMSE)对患者的认知状况和患者的酒精摄入进行评估,包括饮料类型,是由病人的主要看护人报告。一般使用估计方程分析,以确定是否基线酒精的使用与认知能力下降的速度有关。 结果:重度饮酒者(8次或更多的酒精饮料/周)有一个更快的认知能力下降,与mMMSE戒酒者(P = 0.001)相比,每年恶化1.849%,或与轻中度饮酒者(1-7酒精饮料/周)(P = 0.008)相比,每年恶化2.444%。,比较轻中度饮酒者戒酒者无显着差异。提高硬白酒类标准的饮料,而不是啤酒或葡萄酒,还拥有更快的认知功能下降率相关(β= -0.117 P = 0.001)。 结论:在阿尔茨海默病患者中,大量的酒精消费和更硬的酒与一个更快的认知下降率有关,这表明他们可能会加速进展的阿尔茨海默病。我们的研究结果表明,饮酒习惯可能会改变阿尔茨海默病患者过程。
关键词: 酒精,阿尔茨海默病,认知功能减退,痴呆,疾病进展,烈性酒,流行病学危险因素
Current Alzheimer Research
Title:The Association Between Alcohol Use and the Progression of Alzheimer’s Disease
Volume: 13 Issue: 12
Author(s): Devorah Heymann, Yaakov Stern, Stephanie Cosentino, Oksana Tatarina-Nulman, Jhedy N. Dorrejo, Yian Gu
Affiliation:
关键词: 酒精,阿尔茨海默病,认知功能减退,痴呆,疾病进展,烈性酒,流行病学危险因素
摘要: Objective: To examine the relationship between alcohol, both the amount and type, and cognitive decline in a cohort of Alzheimer’s disease (AD) patients.
Methods: A cohort of 360 patients with early AD in New York, Boston, Baltimore and Paris were followed-up biannually for up to 19.28 years. At each visit, the cognitive profile of the patients was assessed using the modified Mini-Mental State Examination (mMMSE), and patients’ alcohol intake, including beverage type, was reported by patients’ primary caregivers. General estimating equation analysis was used to determine whether baseline alcohol use was associated with the rate of cognitive decline.
Results: Heavy drinkers (8 or more alcoholic drinks/week) had a faster cognitive decline, deteriorating 1.849 more points on their mMMSE score annually compared to abstainers (P = 0.001), or 2.444 more points compared to mild-moderate drinkers (1-7 alcoholic drinks/week) (P = 0.008). There was no significant difference when comparing mild-moderate drinkers to abstainers. Increasing standard drinks of hard liquor, but not beer or wine, was also associated with a faster rate of cognitive decline (β = -0.117 P = 0.001).
Conclusion: Heavy alcohol consumption and more hard liquor are associated with a faster rate of cognitive decline in AD patients, suggesting that they may hasten progression of AD. Our results suggest that alcohol drinking habits might alter the course of AD.
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Devorah Heymann, Yaakov Stern, Stephanie Cosentino, Oksana Tatarina-Nulman, Jhedy N. Dorrejo, Yian Gu , The Association Between Alcohol Use and the Progression of Alzheimer’s Disease, Current Alzheimer Research 2016; 13 (12) . https://dx.doi.org/10.2174/1567205013666160603005035
DOI https://dx.doi.org/10.2174/1567205013666160603005035 |
Print ISSN 1567-2050 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5828 |
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Neuroinflammation is an invariable hallmark of chronic and acute neurodegenerative disorders and has long been considered a potential drug target for Alzheimer?s disease (AD) and dementia. Significant evidence of inflammatory processes as a feature of AD is provided by the presence of inflammatory markers in plasma, CSF and postmortem brain ...read more
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