摘要
背景：阿尔茨海默氏病（AD）老年人痴呆最常见的原因，现在不能阻止，停止，或颠倒到。大量的药理研究机构透露，六味地黄汤（LW），中医经典方剂，对AD具有潜在的治疗效果。LW-AFC是LW关键组分。 方法：通过行为实验评价认知能力。采用多重磁珠分析法，免疫化学发光分析法和酶联免疫吸附剂测定法决定因子和激素的水平。脾细胞的增殖及外周血淋巴细胞亚群分别用3H-TdR掺入法和流式细胞仪分析法。 结果：本研究显示LW-AFC治疗延缓快速老化小鼠易感8品系（SAMP8）衰老过程，（SAMP8）是一个强大散发性AD或迟发性/老年性AD的模型。LW-AFC对自发活动，对象识别存储器，空间学习与记忆，SAMP8小鼠的被动和主动回避障碍的有改善作用。LW-AFC恢复不平衡的下丘脑-垂体-肾上腺（HPA）和下丘脑-垂体-性腺（HPG）轴，增强小鼠脾淋巴细胞增殖，校正淋巴细胞亚群紊乱，并调节SAMP8小鼠细胞因子的生产异常。。对SAMP8小鼠神经内分泌免疫调节网络的药效LW-AFC效果优于美金刚胺和盐酸多奈哌齐。 结论：这些数据表明LW-AFC可能是一个有希望的治疗药物
关键词: 六味地黄苷糖，六味地黄汤，阿尔茨海默病，快速老化小鼠，prone 8 strain，认知行为，神经内分泌，脾细胞增殖，淋巴细胞亚群，细胞因子
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