摘要
背景:近几十年来,纳米粒子领域的迅速发展使其在药物传递方法中的应用越来越广泛。纳米给药系统的优点多发性硬化症包括提高药物的治疗效果和减少副作用。 目的:本综述旨在着重介绍利用聚合物纳米粒进行刺激药物释放的方法的进展,重点是pH敏感的药物和热释药系统。 结果与结论:在各种有机/无机纳米粒子中,聚合物纳米粒子凭借易易公司在药物释放系统的发展中发挥了不可或缺的作用。在长时间内与控释药物结合,对靶向分子进行操作和修饰。此外,聚合物纳米粒子通过掺入成像剂除了治疗。近年来,作为智能药物载体的聚合物纳米粒子出现了,其中药物的释放受到物理和/或化学结构的影响。特定刺激引起的铝变化(如ph值、温度和特定酶)。这些材料的使用降低了药物提前释放,维持有效药物浓度在病理学目标。
关键词: 药物传递,药物载体,纳米技术,pH敏感,纳米粒子,癌症治疗,热疗法。
图形摘要
Current Drug Targets
Title:Recent Advances in pH-Sensitive Polymeric Nanoparticles for Smart Drug Delivery in Cancer Therapy
Volume: 19 Issue: 4
关键词: 药物传递,药物载体,纳米技术,pH敏感,纳米粒子,癌症治疗,热疗法。
摘要: Background: Rapid developments in the field of nanoparticles during the last decades have led to its increased application in drug delivery approaches. The advantages of nano-based drug delivery systems include improved therapeutic efficacy of drugs and the reduction of side effects.
Objective: This review aims to highlight advances in stimuli-triggered drug delivery approaches using polymeric nanoparticles with a focus on pH-sensitive drug- and theranostic delivery systems.
Results and Conclusion: Of the various organic/inorganic nanoparticles, polymeric nanoparticles have fulfilled an integral role in the advancement of drug delivery systems by virtue of the ease to incorporate and modify targeting moieties in combination with controlled drug release over prolonged periods. Furthermore, polymeric nanoparticles facilitate theranostic treatment by the incorporation of imaging agents in addition to therapeutics. Recently, stimuli-responsive polymeric nanoparticles emerged as smart drug carriers, in which drug release is affected by physical and/or chemical structural changes induced by a specific stimulus (e.g. pH, temperature, and specific enzymes). The use of these nanocomposites reduces premature drug release and maintains effective drug levels at the pathological target.
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Cite this article as:
Recent Advances in pH-Sensitive Polymeric Nanoparticles for Smart Drug Delivery in Cancer Therapy, Current Drug Targets 2018; 19 (4) . https://dx.doi.org/10.2174/1389450117666160602202339
DOI https://dx.doi.org/10.2174/1389450117666160602202339 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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