Immunotoxicity of Metal Oxide and Metal Nanoparticles and Animal Models to Evaluate Immunotoxicity of Nanoparticles

Title:Immunotoxicity of Metal Oxide and Metal Nanoparticles and Animal Models to Evaluate Immunotoxicity of Nanoparticles

Volume: 2 Issue: 2

Author(s): Han Goo Kang, Jiyoung Jang and In-Hong Choi

Affiliation:

Keywords: Nanoparticles, metal, metal oxide, immunotoxicity, animal model.

Abstract: Since metal (silver and gold) and metal oxide (TiO₂, ZnO, SiO₂) nanoparticles (NPs) are widely used in diagnostics, therapeutics, and commercial products, specialized immuno-toxicity studies are necessary to ensure their safe use in humans. In this article, we review the immunological toxicity of engineered nanomaterials (ENMs), including metal oxide and metal NPs, and suggest animal models of immunological disease suited to study the immunological effects of NPs. Administration of NPs at subtoxic doses in animals with a background of immunological diseases, especially those with allergic or inflammatory diseases, will accelerate our understanding of the precise immunotoxicity and immunestimulatory effects of NPs following real-life exposures.

Cite this article as:

Kang Goo Han, Jang Jiyoung and Choi In-Hong, Immunotoxicity of Metal Oxide and Metal Nanoparticles and Animal Models to Evaluate Immunotoxicity of Nanoparticles, Current Bionanotechnology (Discontinued) 2016; 2 (2) . https://dx.doi.org/10.2174/2213529402666160601112729

DOI https://dx.doi.org/10.2174/2213529402666160601112729	Print ISSN 2213-5294
Publisher Name Bentham Science Publisher	Online ISSN 2213-5308