Marine Depsipeptides as Promising Pharmacotherapeutic Agents

Title:Marine Depsipeptides as Promising Pharmacotherapeutic Agents

Volume: 18 Issue: 1

Author(s): Marisa Rangel, Carlos José Correia de Santana, Andréia Pinheiro, Lilian dos Anjos, Tania Barth, Osmindo Rodrigues Pires Júnior, Wagner Fontes and Mariana S. Castro

Affiliation:

Keywords: Bioactive, marine depsipeptides, mechanism of action, therapeutic agents.

Abstract: Depsipeptides are a group of biologically active peptides that have at least one of the amide bonds replaced by an ester bond. These peptides sometimes present additional chemical modifications, including unusual amino acid residues in their structures. Depsipeptides are known to exhibit a large array of bioactivities, such as anticancer, antiproliferative, antimicrobial, antiviral and antiplasmodial properties. They are commonly found in marine organisms: bacteria, tunicates, mollusks, sponges, and others. Herein, we summarize the latest insights about marine depsipeptides, their mechanisms of action and potential as therapeutic agents.

Cite this article as:

Rangel Marisa, Santana José Correia de Carlos, Pinheiro Andréia, Anjos dos Lilian, Barth Tania, Júnior Rodrigues Pires Osmindo, Fontes Wagner and Castro S. Mariana, Marine Depsipeptides as Promising Pharmacotherapeutic Agents, Current Protein & Peptide Science 2017; 18 (1) . https://dx.doi.org/10.2174/1389203717666160526122130