Abstract
The chemistry of lithiated α-chloroalkylheterocycles such as α-chloroalkylbenzothiazoles, - benzotriazoles, -pyridines, -triazines, -thiazoles and -oxazolines has been reviewed. The synthetic application of this kind of chemistry for the stereoselective preparation of heteroaryl cyclopropanes, oxiranes, aziridines, alkenes and functionalised nitroarenes through a Darzens-type reaction, has been especially emphasised.
Keywords: carbenoids, haloalkyllithiums, chemistry, reagents, reactions, ring expansion, heterocyclic ring
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
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