1,4-Diazabicyclo[2.2.2]octanium Diacetate: As a New, Effective and Reusable Catalyst for the Synthesis of 3,4- dihydropyrimidin-2(1H)-ones and -Thiones

Title:1,4-Diazabicyclo[2.2.2]octanium Diacetate: As a New, Effective and Reusable Catalyst for the Synthesis of 3,4- dihydropyrimidin-2(1H)-ones and -Thiones

Volume: 13 Issue: 6

Author(s): Leila Zare Fekri and Mahsa Movaghari

Affiliation:

Keywords: Biginelli reaction, ethyl acetoacetate, ionic liquid, solvent free, thiourea, urea.

Abstract: In this study, a new, effective and environmentally benign procedure for the synthesis of dihydropyrimidinone and thione derivatives with various benzaldehydes, urea or thiourea, and ethyl acetoacetate in the presence of 1,4-diazabicyclo[2.2.2]octanium diacetate as a novel acidic ionic liquid, in high yield and short reaction time is reported. This method provides several advantages such as easy work-up, green, environmental friendliness and fast reaction condition along with high yields.

Cite this article as:

Fekri Zare Leila and Movaghari Mahsa, 1,4-Diazabicyclo[2.2.2]octanium Diacetate: As a New, Effective and Reusable Catalyst for the Synthesis of 3,4- dihydropyrimidin-2(1H)-ones and -Thiones, Letters in Organic Chemistry 2016; 13 (6) . https://dx.doi.org/10.2174/1570178613666160524160125