在高糖条件下，地骨皮提取物保护胰腺β细胞

Title:Cortex Lycii Radicis Extracts Protect Pancreatic Beta Cells Under High Glucose Conditions

Volume: 16 Issue: 6

Author(s): D. Wang and Z. Ye

Affiliation:

关键词: 胰腺β细胞，地骨皮，细胞增殖，细胞凋亡，自噬，糖尿病。

摘要: The normal function of pancreatic beta cells is vital to the control of blood glucose. Earlier research suggests that the traditional Chinese medicine Cortex Lycii Radicis may help protect pancreatic beta cells and improve insulin sensitivity. However, the specific effects and molecular mechanism of this herb have not been described. Thus, we investigated the role of Cortex Lycii Radicis in regulating the proliferation, apoptosis, and autophagy of INS-1 pancreatic beta cells. Our study revealed that Cortex Lycii Radicis extracts could promote INS-1 cell proliferation and inhibit cell apoptosis under high glucose conditions. We also evaluated the formation of autophagosomes and found that GFP-LC3 fusion protein was translocated to the autophagosome membrane. Autophagosomes increased in the group treated with Cortex Lycii Radicis compared with the no treatment control group, indicating that these extracts could promote the activation of autophagy in INS-1 cells. Our findings suggest a significant association of the Cortex Lycii Radicis extracts treatment with apoptosis and autophagy, which protects the function of pancreatic beta cells, providing evidence for the development of a new drug for diabetes treatment.

Cite this article as:

D. Wang and Z. Ye , Cortex Lycii Radicis Extracts Protect Pancreatic Beta Cells Under High Glucose Conditions, Current Molecular Medicine 2016; 16 (6) . https://dx.doi.org/10.2174/1566524016666160523143757