摘要
人类Hole(hHole)基因编码着有着319个氨基酸的6-跨膜蛋白。我们以往的研究表明,hHole在成人心脏中强烈表达,可以抑制细胞外信号调节激酶(ERK),过度激活会导致病理性心肌肥厚。在这项研究中,观察到在小鼠肥厚性心脏中Hole基因表达上调。在心脏特异性转基因小鼠模型中,观察到Hole基因特异性在心脏过度表达可以抑制异丙肾上腺素(ISO)引起的心肌肥厚和纤维化,钝化的ERK1/2、总的ERK1/2蛋白和磷酸化ERK1/2(ERK1/2)转录水平。此外,水尾静脉注射hHole质粒的小鼠hhole基因过表达也能抑制ISO诱导的心肌肥大。我们的工作确定了hHole基因作为一种新型的心肌肥厚的抑制剂,并提供了为心脏疾病的预防和治疗可能目标的新的见解。
关键词: 心肌肥厚;人Hole基因(hHole);异丙肾上腺素(ISO);细胞外信号调节激酶(ERK)。
Current Molecular Medicine
Title:Cardiac Specific Overexpression of hHole Attenuates Isoproterenol–Induced Hypertrophic Remodeling through Inhibition of Extracellular Signal-Regulated Kinases (ERKs) Signalling
Volume: 16 Issue: 5
Author(s): W. Xu, Y. Wang, J. Zhou, X. Zhu, S. Zhang, W. Yuan, X. Liu, Y. Shi, L. Cao, Q. Zeng, Z. Jiang, X. Ye, Y. Wan, X. Peng, Y. Deng and F. Chen, X. Wang, G. Dai, S. Luo, X. Fan, X. Mo, X. Wu, Y. Li
Affiliation:
关键词: 心肌肥厚;人Hole基因(hHole);异丙肾上腺素(ISO);细胞外信号调节激酶(ERK)。
摘要: The human Hole gene (hHole) encodes a six-transmembrane protein with 319- amino acids. Our previous study showed that hHole was strongly expressed in adult heart and may act as a suppressor of extracellular signal-regulated kinases (ERKs), overactivation of which contributed to pathological cardiac hypertrophy. In this study, it was observed that Hole expression was up-regulated in murine hypertrophic hearts. In a cardiac specific transgenic mouse model, it was observed that overexpression of hHole specifically in heart attenuated cardiac hypertrophy and fibrosis induced by isoproterenol (ISO), with blunted transcriptions of ERK1/2, total ERK1/2 proteins and phosphorylated ERK1/2 (p-ERK1/2) levels. Furthermore, overexpression of hHole in mice by hydrodynamic tail-vein injection with hHole plamids also inhibited cardiac hypertrophy induced by ISO. Our work identified hHole as a novel repressor of cardiac hypertrophy, and provided new insights into the possible target for the prevention or treatment of cardiac diseases.
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Cite this article as:
W. Xu, Y. Wang, J. Zhou, X. Zhu, S. Zhang, W. Yuan, X. Liu, Y. Shi, L. Cao, Q. Zeng, Z. Jiang, X. Ye, Y. Wan, X. Peng, Y. Deng and F. Chen, X. Wang, G. Dai, S. Luo, X. Fan, X. Mo, X. Wu, Y. Li , Cardiac Specific Overexpression of hHole Attenuates Isoproterenol–Induced Hypertrophic Remodeling through Inhibition of Extracellular Signal-Regulated Kinases (ERKs) Signalling, Current Molecular Medicine 2016; 16 (5) . https://dx.doi.org/10.2174/1566524016666160523143704
DOI https://dx.doi.org/10.2174/1566524016666160523143704 |
Print ISSN 1566-5240 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5666 |
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