Abstract
Threonine-proline chimeras are not so abundant in nature as the other proine-chimeras and their functionalization is also restricted to the third position on the pyrrolidine ring. Despite these aspects the synthetic procedures adopted to obtain these products are straightforward and well-described in literature, as reported in the following review.
Keywords: Threonine-proline chimeras, diastereoselective cyclization, Sharpless epoxidation, Deckmann reaction, Michael condensation.
Graphical Abstract
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