Abstract
It is well known that over the time each species has directed a specific function of its metabolic activity for survival, development and perpetuation, towards a sustained seeking for a balance with the surrounding environment. In this respect, plants became a major point of interest for the pharmaceutical industry due to their capacity of synthetizing organic compounds with specific pharmacological activity, most of them as secondary metabolites. Several major classes of chemical compounds, i.e. flavones, phenolics, terpenoids and essential oils, alkaloids, lectins and polypeptides, and polyacetylenes are phytochemicals with important antimicrobial activity and, besides them, some other natural compounds involved in inter-kingdom communication, such as quorum sensing molecules or natural antimicrobial peptides. These compounds have been proposed as potential alternatives to antibiotics for fighting infectious diseases. Extensive research has been made regarding the antimicrobial efficiency for a plethora of such natural compounds, but, unfortunately, lesser importance has been given to the occurrence of microbial resistance to them. In this respect, our aim was to review the literature, highlighting the latest findings on this topic, for a comprehensive view regarding the risk of using antimicrobials from natural sources in selecting microbial resistance.
Keywords: Microbial resistance, natural compounds, antibiotics.
Graphical Abstract
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
Related Books
Advances in Organic Synthesis
The Synthetic Methods, Structures, and Properties of the Ca-C σ Bond Organocalcium Containing Compounds
Advances in Organic Synthesis
Chemistry of Bipyrazoles: Synthesis and Applications
Advances in Organic Synthesis
Advanced Nanocatalysis for Organic Synthesis and Electroanalysis
Advances in Organic Synthesis
Advances in Organic Synthesis
41
1
1
1