The Application of Molecular Tethers in Controlling Axial Chirality

Michael      Reen; Timothy      P. O`Sullivan

doi:10.2174/1570193X13666160510114626

Abstract

Atropisomeric biaryl compounds are an attractive target in organic chemistry due to their abundance in nature and their utility as ligands in catalysis. Among the methods available for their synthesis, the use of chiral tethers offers very high levels of stereocontrol. In this article, we review the application of molecular tethers in controlling axial chirality across a range of different ligands and natural products.

Keywords: Atropisomeric biaryl compound, axial chirality, biaryls, stereoinduction, synthesis, tethers.

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Mini-Reviews in Organic Chemistry

Title:The Application of Molecular Tethers in Controlling Axial Chirality

Volume: 13 Issue: 3

Author(s): Michael Reen and Timothy P. O`Sullivan

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Keywords: Atropisomeric biaryl compound, axial chirality, biaryls, stereoinduction, synthesis, tethers.

Abstract: Atropisomeric biaryl compounds are an attractive target in organic chemistry due to their abundance in nature and their utility as ligands in catalysis. Among the methods available for their synthesis, the use of chiral tethers offers very high levels of stereocontrol. In this article, we review the application of molecular tethers in controlling axial chirality across a range of different ligands and natural products.

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Reen Michael and P. O`Sullivan Timothy, The Application of Molecular Tethers in Controlling Axial Chirality, Mini-Reviews in Organic Chemistry 2016; 13 (3) . https://dx.doi.org/10.2174/1570193X13666160510114626

DOI https://dx.doi.org/10.2174/1570193X13666160510114626	Print ISSN 1570-193X
Publisher Name Bentham Science Publisher	Online ISSN 1875-6298