Abstract
Pressurised metered dose inhalers (pMDI) are still the most heavily prescribed medicines for the treatment of asthma. Various add-on devices are made available through pharmacies either on prescription, over-the-counter or off-theshelf. These include actuation aids, spacers and alternative actuators. The Sports- Haler™ is a replacement actuator for the conventional Ventolin™ actuator and offers a compact and colourful alternative to the conventional design. This article evaluates the performance of this replacement device and compares it to the standard product using Pharmacopeia methodology. In general, there were no differences in the aerosol performance and thus projected lung deposition of salbutamol sulphate. We discuss the pros and cons of such add-on devices from a pharmacy perspective and highlight potential issues that may be encountered when patients choose to modify the standard regulated pharmaceutical product. There are several considerations, which need to be reviewed when making decisions about the use of substitute and/or add-on devices.
Keywords: Equivalence, device education, inhalation add-on devices, inhaler use.
Graphical Abstract
Drug Delivery Letters
Title:Substitute and Add-on Devices Used in Inhalation Therapy: is it Safe to Recommend Replacing the Ventolin™ Actuator with the Sports-Haler™
Volume: 6 Issue: 1
Author(s): Sinthia Bosnic-Anticevich, Sophia Mavritsakis, Susan Hoe, Paul M. Young and Daniela Traini
Affiliation:
Keywords: Equivalence, device education, inhalation add-on devices, inhaler use.
Abstract: Pressurised metered dose inhalers (pMDI) are still the most heavily prescribed medicines for the treatment of asthma. Various add-on devices are made available through pharmacies either on prescription, over-the-counter or off-theshelf. These include actuation aids, spacers and alternative actuators. The Sports- Haler™ is a replacement actuator for the conventional Ventolin™ actuator and offers a compact and colourful alternative to the conventional design. This article evaluates the performance of this replacement device and compares it to the standard product using Pharmacopeia methodology. In general, there were no differences in the aerosol performance and thus projected lung deposition of salbutamol sulphate. We discuss the pros and cons of such add-on devices from a pharmacy perspective and highlight potential issues that may be encountered when patients choose to modify the standard regulated pharmaceutical product. There are several considerations, which need to be reviewed when making decisions about the use of substitute and/or add-on devices.
Export Options
About this article
Cite this article as:
Bosnic-Anticevich Sinthia, Mavritsakis Sophia, Hoe Susan, Young M. Paul and Traini Daniela, Substitute and Add-on Devices Used in Inhalation Therapy: is it Safe to Recommend Replacing the Ventolin™ Actuator with the Sports-Haler™, Drug Delivery Letters 2016; 6 (1) . https://dx.doi.org/10.2174/2210303106666160506151721
DOI https://dx.doi.org/10.2174/2210303106666160506151721 |
Print ISSN 2210-3031 |
Publisher Name Bentham Science Publisher |
Online ISSN 2210-304X |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Recent Advancement in the Treatment of Cardiovascular Diseases: Conventional Therapy to Nanotechnology
Current Pharmaceutical Design Oxidative Stress and the Use of Antioxidants for the Treatment of Rheumatoid Arthritis
Current Medicinal Chemistry - Immunology, Endocrine & Metabolic Agents Medicinal Plants and Natural Products: More Effective and Safer Pharmacological Treatment for the Management of Obesity
Current Drug Metabolism Controlled Release Inhalable Polymeric Microspheres for Treatment of Pulmonary Arterial Hypertension
Current Pharmaceutical Design Inhibition of Mitogen-Activated Protein Kinases (MAPKs) as a Strategy to Prevent Intimal Hyperplasia Following Cardiovascular Interventions
Vascular Disease Prevention (Discontinued) Recent Advances in the Synthesis and Development of Curcumin, its Combinations and Formulations and Curcumin-like Compounds as Anti-infective Agents
Current Medicinal Chemistry Mechanical Ventilation Following Cardiac Surgery in Children
Current Respiratory Medicine Reviews Optimisation of DMPK by the Inhaled Route: Challenges and Approaches
Current Drug Metabolism Involvement of Cannabinoids in Cellular Proliferation
Mini-Reviews in Medicinal Chemistry Novel Strategies for the Treatment of Asthma
Recent Patents on Inflammation & Allergy Drug Discovery Fluorescence-Based Adenylyl Cyclase Assay Adaptable to High Throughput Screening
Combinatorial Chemistry & High Throughput Screening Immunotherapeutic Targeting of Allergic Disease
Inflammation & Allergy - Drug Targets (Discontinued) n-3 Fatty Acids: Role in Neurogenesis and Neuroplasticity
Current Medicinal Chemistry Regulatory T Cells in Central Nervous System: in Health and Disease
Central Nervous System Agents in Medicinal Chemistry Household Typology and Family Social Capital Among White British and Pakistani Women in Bradford, England
Current Women`s Health Reviews Use of Ceramides and Related Products for Childhood-Onset Eczema
Recent Patents on Inflammation & Allergy Drug Discovery Future Treatment for COPD: Targeting Oxidative Stress and its Related Signal
Recent Patents on Inflammation & Allergy Drug Discovery Evaluating Protein-protein Interaction (PPI) Networks for Diseases Pathway, Target Discovery, and Drug-design Using `In silico Pharmacology`
Current Protein & Peptide Science Does Inhaled Corticosteroid Treatment Result in a Secondary Immune Deficiency Predisposing To Recurrent Infections?
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry Ginkgolic Acids Confer Potential Anticancer Effects by Targeting Pro- Inflammatory and Oncogenic Signaling Molecules
Current Molecular Pharmacology