Abstract
Objective/Method: A series of 4H-chromen-4-one derivatives (A1-A16) have been designed and synthesized, and they were screened for BRAF kinase inhibitory activity. Furthermore, their biological activities were evaluated in vitro.
Result: Compounds A03 and A10 displayed the most potent antiproliferative activity against human osteosarcoma cell line (U2OS) and A16 displayed the most potent antiproliferative activity against human melanoma cancer cell line (A375) in vitro, which was valuable to study further.Keywords: 4H-Chromen-4-one, anticancer activity, BRAF (V600E) kinase, design, in vitro, synthesis.
Graphical Abstract
Anti-Cancer Agents in Medicinal Chemistry
Title:Synthesis and Anticancer Study of Novel 4H-Chromen Derivatives
Volume: 17 Issue: 8
Author(s): Xiaolin Lu, Gaochao Dong, Ying Zheng, Chao Zhang, Yang Qiu, Tao Lua and Xiang Zhou*
Affiliation:
- Department of Science, China Pharmaceutical University, 639 Longmian Avenue, Nanjing, Jiang Su, 211198,China
Keywords: 4H-Chromen-4-one, anticancer activity, BRAF (V600E) kinase, design, in vitro, synthesis.
Abstract: Objective/Method: A series of 4H-chromen-4-one derivatives (A1-A16) have been designed and synthesized, and they were screened for BRAF kinase inhibitory activity. Furthermore, their biological activities were evaluated in vitro.
Result: Compounds A03 and A10 displayed the most potent antiproliferative activity against human osteosarcoma cell line (U2OS) and A16 displayed the most potent antiproliferative activity against human melanoma cancer cell line (A375) in vitro, which was valuable to study further.Export Options
About this article
Cite this article as:
Lu Xiaolin, Dong Gaochao, Zheng Ying, Zhang Chao, Qiu Yang, Lua Tao and Zhou Xiang*, Synthesis and Anticancer Study of Novel 4H-Chromen Derivatives, Anti-Cancer Agents in Medicinal Chemistry 2017; 17 (8) . https://dx.doi.org/10.2174/1871520615666160504094945
DOI https://dx.doi.org/10.2174/1871520615666160504094945 |
Print ISSN 1871-5206 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5992 |
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