摘要
背景:了解miRNAs在破骨细胞中的作用,在骨溶解疾病的诊断和治疗中具有很大的潜力。 目的:综述miRNA在破骨细胞中的作用,并对miRNA生物发生的研究现状进行综述。 结果:大量证据表明miRNAs是一种新的有效调控基因表达的机制。 结论:阐明miRNAs在破骨过程中的作用,将为溶骨疾病的治疗提供新的治疗策略和药物靶点。还有很多问题,但是深入理解miRNAs表达的网络和动力学,以及它们与同源基因的联系将不是琐碎的,而是富有成果的。
关键词: 药物靶点,miRNAs,破骨细胞,骨溶解疾病,骨稳态,生物发生。
图形摘要
Current Drug Targets
Title:MicroRNAs as Potential Targets for Treatment of Osteoclast-Related Diseases
Volume: 19 Issue: 5
关键词: 药物靶点,miRNAs,破骨细胞,骨溶解疾病,骨稳态,生物发生。
摘要: Background: Understanding the roles of miRNAs in osteoclasts has great potential in the diagnosis and treatment of osteolytic diseases.
Objective: The purpose of this paper was to describe the current knowledge of miRNA biogenesis and summarize recent work on the roles of miRNAs in osteoclasts.
Results: There is accumulating evidence to indicate that miRNAs constitute a novel and efficient mechanism for the regulation of gene expression.
Conclusion: Untangling the role that miRNAs play in osteoclastogenesis will illuminate new strategies and specific drug targets for the treatment of osteolytic diseases. Many questions remain, but an in-depth comprehension of the network and kinetics of miRNAs expression, and their connection with cognate genes will not be trivial, but fruitful.
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Cite this article as:
MicroRNAs as Potential Targets for Treatment of Osteoclast-Related Diseases, Current Drug Targets 2018; 19 (5) . https://dx.doi.org/10.2174/1389450117666160502144329
DOI https://dx.doi.org/10.2174/1389450117666160502144329 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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