治疗认知障碍和情绪障碍的抗糖尿病药物的再利用

Title:Repurposing of Anti-Diabetic Agents for the Treatment of Cognitive Impairment and Mood Disorders

Volume: 16 Issue: 5

Author(s): D.S. Cha, M. Vahtra, J. Ahmed, P.A. Kudlow, R.B. Mansur, A.F. Carvalho, R.S. McIntyre

Affiliation:

关键词: 抑郁症；双极性；糖尿病；老年痴呆症；阿尔茨海默病；胰岛素；胰岛素抵抗；GLP-1；肠促胰岛素；噻唑烷二酮；二甲双胍；认知。

摘要: Impairments in cognitive function represent a consistent, non-specific, and clinically significant feature in metabolic, mood, and dementing disorders. The foregoing observation is instantiated by evidence demonstrating that these disorders share pathophysiological mechanisms including, but not limited to, aberrant insulin signaling, inflammation, and glucocorticoid activity. Moreover, these mechanisms have been consistently reported to increase vulnerability to and/or exacerbate impairments in cognitive function. Notwithstanding evidence suggesting a bidirectional relationship between disturbances in the metabolic milieu, mood, and increased risk for dementia, efficacious treatments that target cognitive impairments in these populations do not presently exist. Taken together, it is proposed that anti-diabetic agents may aid the management of mood disorders and future risk for dementia through disease modification by targeting underlying pathophysiological mechanisms (e.g., aberrant metabolic function) rather than focusing solely on symptom mitigation. The current aim is to provide a brief narrative review of extant studies that report on the potential neurotherapeutic effects of anti-diabetic agents on disturbances in mood and impairments in cognitive function.

Cite this article as:

D.S. Cha, M. Vahtra, J. Ahmed, P.A. Kudlow, R.B. Mansur, A.F. Carvalho, R.S. McIntyre , Repurposing of Anti-Diabetic Agents for the Treatment of Cognitive Impairment and Mood Disorders, Current Molecular Medicine 2016; 16 (5) . https://dx.doi.org/10.2174/1566524016666160429121737