摘要
miRNA表达失调已在各种人类癌症被观察到,包括肺癌。最近的研究已经确定,一些miRNA在调控关键细胞信号通路和肺肿瘤的发生,包括细胞增殖、分化、血管生成、细胞凋亡、侵袭和转移的作用。由于它们的变量的行为和监管的细胞通路各节点连接的作用,miRNA也被用作肺癌的潜在治疗靶点和临床生物标志物。在这种非系统性综述中,简要对水稻miRNA与甲基化在非小细胞肺癌组织中miRNA的生物合成的调控作用的生物合成和功能集中(NSCLC)。此外,我们详细阐明了表达差异的miRNA及其在各种信号通路、细胞周期、细胞凋亡、细胞的调控作用。
关键词: 非小细胞肺癌;微小RNA;细胞周期;细胞信号转导;细胞凋亡。
Current Molecular Medicine
Title:Role of microRNA in Regulating Cell Signaling Pathways, Cell Cycle, and Apoptosis in Non-Small Cell Lung Cancer
Volume: 16 Issue: 5
Author(s): D.K. Singh, S. Bose, S. Kumar
Affiliation:
关键词: 非小细胞肺癌;微小RNA;细胞周期;细胞信号转导;细胞凋亡。
摘要: Dysregulation in the expression of miRNAs has been observed in various human cancers, including lung cancer. Recent studies have identified the role of a number of miRNAs in regulating key cellular processes and signaling pathways involved in lung tumourigenesis, including cell proliferation, differentiation, angiogenesis, apoptosis, invasion and metastasis. Due to their variable behavior and regulatory role in various nodal junctions in cellular pathways, miRNAs have also been used as potential therapeutic targets and clinical biomarkers in lung cancer. In this non-systematic review, we briefly focus on biogenesis and function of cytoplasmic miRNA and the role of methylation in the regulation of miRNA biogenesis in non-small cell lung cancer (NSCLC). Further, we elaborate the role of differentially expressed miRNAs and their regulatory role on various signaling pathways, cell cycle, and apoptosis in NSCLC.
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Cite this article as:
D.K. Singh, S. Bose, S. Kumar , Role of microRNA in Regulating Cell Signaling Pathways, Cell Cycle, and Apoptosis in Non-Small Cell Lung Cancer, Current Molecular Medicine 2016; 16 (5) . https://dx.doi.org/10.2174/1566524016666160429120702
DOI https://dx.doi.org/10.2174/1566524016666160429120702 |
Print ISSN 1566-5240 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5666 |
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