在情绪障碍和精神分裂症中褪黑激素与线粒体相互作用的重要性：当前的评估

Title:The Importance of Melatonin and Mitochondria Interaction in Mood Disorders and Schizophrenia: A Current Assessment

Volume: 23 Issue: 20

Author(s): Abdülhadi Cihangir Uguz, Kadir Demirci, Javier Espino

Affiliation:

关键词: 双相情感障碍；钙信号；抑郁；线粒体；心境障碍；氧化应激；精神分裂症。

摘要: Mitochondria play a critical role in regulating cellular functions, such as redox signaling, calcium homeostasis, and apoptosis. Also, mitochondria are crucial for neurogenesis and neuronal functions. Melatonin is an indole analog hormone, which is generally produced by the pineal gland. It plays a vital role in circadian rhythm and act as a powerful antioxidant by scavenging free radicals, immunomodulators, and anticancer agents. Schizophrenia and mood disorders are the two major psychiatric disorders. Disturbances of sleep and circadian rhythms are well-known symptoms of schizophrenia and mood disorders (bipolar disorder, major depression). Since melatonin has a regulator effect on circadian rhythm and sleep quality, it has a close interaction with schizophrenia and mood disorders. Herein, we aimed to summarize the effects of melatonin on mitochondrial activity in schizophrenia and mood disorders.

Cite this article as:

Abdülhadi Cihangir Uguz, Kadir Demirci, Javier Espino , The Importance of Melatonin and Mitochondria Interaction in Mood Disorders and Schizophrenia: A Current Assessment, Current Medicinal Chemistry 2016; 23 (20) . https://dx.doi.org/10.2174/0929867323666160428105849