A Case Report of Antitubercular Drugs Induced Exanthematous Reaction Complicated by Acute Onset Levofloxacin Induced Toxic Epidermal Necrolysis (TEN)

Title:A Case Report of Antitubercular Drugs Induced Exanthematous Reaction Complicated by Acute Onset Levofloxacin Induced Toxic Epidermal Necrolysis (TEN)

Volume: 13 Issue: 1

Author(s): Khushboo Gajjar*, Hiren Hirapara, Chandra Sekhar Jaiswal, Manish Barvaliya, Hita Shah and Chandrabhanu Rajkishor Tripathi

Affiliation:

• Department of Pharmacology, Government Medical College and Sir Takhtsinhji General Hospital, Bhavnagar-364001 (Gujarat),India

Keywords: Exanthematous reaction, levofloxacin, toxic epidermal necrolysis, antituberculer drugs, cutaneous adverse reaction, hypersensitivity.

Abstract: Background: We report a case of 25 years old male patient with antitubercular drugs induced exanthematous reaction and hepatotoxicity that was complicated by levofloxacin induced toxic epidermal necrolysis. The patient was allergic to ciprofloxacin and ofloxacin. Cross reactivity between ciprofloxacin and levofloxacin might be responsible for causing this reaction.

Conclusion: Issues of cross sensitivity should be kept in mind and the same class of drugs should strictly be avoided to prevent such complications.

Cite this article as:

Gajjar Khushboo*, Hirapara Hiren, Jaiswal Sekhar Chandra, Barvaliya Manish, Shah Hita and Tripathi Rajkishor Chandrabhanu , A Case Report of Antitubercular Drugs Induced Exanthematous Reaction Complicated by Acute Onset Levofloxacin Induced Toxic Epidermal Necrolysis (TEN), Current Drug Safety 2018; 13 (1) . https://dx.doi.org/10.2174/1574886311666160427104417