对肿瘤分子靶向治疗物质的更新：端粒酶活性抑制效应的潜力

Title:An Update on Phytochemicals in Molecular Target Therapy of Cancer: Potential Inhibitory Effect on Telomerase Activity

Volume: 23 Issue: 22

Author(s): Abbas Alibakhshi, Javad Ranjbari, Yones Pilehvar-Soltanahmadi, Marzieh Nasiri, Mahdie Mollazade, Nosratollah Zarghami

Affiliation:

关键词: 治疗癌症；植物化学；Telomerase。

摘要: Telomerase is a ribonucleoprotein enzyme, which has a significant role in synthesizing DNA telomeric in eukaryotes. Telomere maintenance can cause to immortalization and malignant transformation of human cells and thereby telomerase activity must be scrutinized as an important factor in most tumor cells. The proliferation of cancer cells or apoptosis induction can be suppressed by telomerase inhibition using different therapeutic agents without any side effects upon normal cells. Natural substances, with anti-tumor effects, such as those derived from plants can be suitable candidates due to their capabilities in preventing some side effects and resistance of tumors with respect to most chemotherapeutic drugs. In this regards, many studies have shown that natural phytochemicals have inhibitory effects on telomerase activity through affecting its subunits and components. Therefore, the aim of this paper is to review the recent studies on these kinds of phytochemicals in terms of property and mechanism. Moreover, strategies for improving the therapeutic efficacy of plant-derived substances such as combination therapy and nanoformulation based approaches are included.

Cite this article as:

Abbas Alibakhshi, Javad Ranjbari, Yones Pilehvar-Soltanahmadi, Marzieh Nasiri, Mahdie Mollazade, Nosratollah Zarghami , An Update on Phytochemicals in Molecular Target Therapy of Cancer: Potential Inhibitory Effect on Telomerase Activity, Current Medicinal Chemistry 2016; 23 (22) . https://dx.doi.org/10.2174/0929867323666160425113705