呫吨酮衍生物药物样作用以及其在体内的吸收、分布、代谢、排泄：临床试验前沿

Title:Drug-like Properties and ADME of Xanthone Derivatives: The Antechamber of Clinical Trials

Volume: 23 Issue: 32

Author(s): Ana Sara Gomes, Pedro Brandão, Carla Sofia Garcia Fernandes, Marta Ramos Pinto Correia da Silva and Maria Emília da Silva Pereira de Sousa, Madalena Maria de Magalhães Pinto

Affiliation:

关键词: 药物发展，代谢，药物代谢动力学，生物化学性质，预临床，呫吨酮，毒性

摘要: Xanthone derivatives have been described as compounds with a privileged scaffold exhibiting diverse biological/pharmacological activities, what directed the interest to pursue the development of these derivatives into drug candidates. Nevertheless, to achieve this purpose it is crucial to study their pharmacokinetics and toxicity (PK/tox) properties as decision endpoints to continue or interrupt the development investment. This review aims to expose the most relevant analytical methods used in the physicochemical and PK/tox studies in order to detect, quantify, and identify different bioactive xanthones. Analyzing the main results from in vitro and in vivo systems towards ADME properties such as solubility, lipophilicity, pKa, chemical and metabolic stability, permeability, transporters modulation, and plasma protein binding, it is possible to uncover some threats governing the PK properties and to understand the bioavailability and drugability of xanthone derivatives. The last section of this review focuses on a case-study of the development of the drug candidate DMXAA, which has reached clinical trials, to provide the paths and the importance of PK/tox parameters of this scaffold. The data assembled in this review intends to guide for tackling issues in the design of potential lead compounds and drug candidates with a xanthone scaffold.

Cite this article as:

Ana Sara Gomes, Pedro Brandão, Carla Sofia Garcia Fernandes, Marta Ramos Pinto Correia da Silva and Maria Emília da Silva Pereira de Sousa, Madalena Maria de Magalhães Pinto , Drug-like Properties and ADME of Xanthone Derivatives: The Antechamber of Clinical Trials, Current Medicinal Chemistry 2016; 23 (32) . https://dx.doi.org/10.2174/0929867323666160425113058