可逆结合PET显像应用于脑成像技术的发展

Title:Considerations in the Development of Reversibly Binding PET Radioligands for Brain Imaging

Volume: 23 Issue: 18

Author(s): Victor W. Pike

Affiliation:

关键词: PET，放射性配体，分子成像、正电子发射体、碳11、氟18、转运、血脑屏障

摘要: The development of reversibly binding radioligands for imaging brain proteins in vivo, such as enzymes, neurotransmitter transporters, receptors and ion channels, with positron emission tomography (PET) is keenly sought for biomedical studies of neuropsychiatric disorders and for drug discovery and development, but is recognized as being highly challenging at the medicinal chemistry level. This article aims to compile and discuss the main considerations to be taken into account by chemists embarking on programs of radioligand development for PET imaging of brain protein targets.

Cite this article as:

Victor W. Pike , Considerations in the Development of Reversibly Binding PET Radioligands for Brain Imaging, Current Medicinal Chemistry 2016; 23 (18) . https://dx.doi.org/10.2174/0929867323666160418114826