Proteins Structures in Leishmania Amastigotes for Clinical Remission of Psoriasis

Title:Proteins Structures in Leishmania Amastigotes for Clinical Remission of Psoriasis

Volume: 13 Issue: 1

Author(s): Jose Antonio O'Daly

Affiliation:

Keywords: Amastigotes vaccine, amino acid sequences, cutaneous leishmaniasis, psoriasis, psoriatic arthritis, rheumatoid arthritis.

Abstract: The aim is to determine amino acid sequences from Leishmania amastigotes, to identify proteins in vaccines for cutaneous leishmaniasis, that also induced clinical remission of psoriasis, psoriatic arthritis and collagen induced arthritis in mice, a serendipity finding, unprecedented in the scientific literature. A third generation AS200 fractions three + four, vaccine from L(V)brasiliensis, were sequenced at Harvard’s microchemistry facility. Proteins were identified by homology with 114 amino acid sequences. The most frequent (14.9%) were: Antithrombin-III, Serine protease inhibitor, bovine followed by Serine proteinase inhibitor, Clade A α-1 antiproteinase, Antitrypsin, Bos Taurus at 9.6% frequency.

Cite this article as:

O'Daly Antonio Jose, Proteins Structures in Leishmania Amastigotes for Clinical Remission of Psoriasis, Current Proteomics 2016; 13 (1) . https://dx.doi.org/10.2174/1570164613666160414115005