Title:Pharmacological Effects of Niacin on Acute Hyperlipemia
Volume: 23
Issue: 25
Author(s): Sergio Montserrat-de la Paz, Beatriz Bermudez, M. Carmen Naranjo, Sergio Lopez, Rocio Abia, Francisco J.G. Muriana
Affiliation:
关键词:
烟酸,维生素B3,高脂血症,富含甘油三酯的脂蛋白,餐后状态,心血管疾病。
摘要: The well-known changes in modern lifestyle habits including over
nutrition and physical inactivity have led to striking adverse effects on public
health (e.g., obesity, diabetes, and metabolic syndrome) over recent decades. One
noticeable consequence is exaggerated and prolonged state of postprandial hyperlipemia
due to the ingestion of multiple fat-enriched meals during the course
of a day. Postprandial (non-fasting) hyperlipemia is characterized by increased
blood levels of exogenous triglycerides (TG) in the form of apolipoprotein (apo)
B48-containing TG-rich lipoproteins (TRL), which have a causal role in the
pathogenesis and progression of cardiovascular disease (CVD). The cardiovascular
benefits of lifestyle modification (healthy diet and exercise) and conventional
lipid-lowering therapies (e.g., statins, fibrates, and niacin) could involve their favourable effects
on postprandial metabolism. Pharmacologically, niacin has been used as an athero-protective drug
for five decades. Studies have since shown that niacin may decrease fasting levels of plasma verylow-
density lipoproteins (VLDL), low-density lipoprotein cholesterol (LDL-C), and lipoprotein
[a] (Lp[a]), while may increase high-density lipoprotein cholesterol (HDL-C). Herein, the purpose
of this review was to provide an update on effects and mechanisms related to the pharmacological
actions of niacin on acute hyperlipemia.