Abstract
Herein, we report the first 48-membered, dansyl-based, combinatorial fluorescent library. From the electronic and structural properties of the probes, we analyzed their optical properties and chemical yields, with an average of 49 %. The molecules were examined for their pH responses, and DS-2 and DS-45 showed blue-shifts, whereas DS-7 and DS-40 showed red-shifts in wavelength with increasing pH. Finally, cell permeability was investigated by treating SNU-2292 cells. Our results demonstrate the potential application of this library in biosensors, bio-imaging and pH indicators.
Keywords: Combinatorial chemistry, dansyl chloride, pH sensor.
Combinatorial Chemistry & High Throughput Screening
Title:Combinatorial Dansyl Library and its Applications to pH-Responsive Probes
Volume: 19 Issue: 5
Author(s): Seong Cheol Hong, Dhiraj P. Murale and Jun-Seok Lee
Affiliation:
Keywords: Combinatorial chemistry, dansyl chloride, pH sensor.
Abstract: Herein, we report the first 48-membered, dansyl-based, combinatorial fluorescent library. From the electronic and structural properties of the probes, we analyzed their optical properties and chemical yields, with an average of 49 %. The molecules were examined for their pH responses, and DS-2 and DS-45 showed blue-shifts, whereas DS-7 and DS-40 showed red-shifts in wavelength with increasing pH. Finally, cell permeability was investigated by treating SNU-2292 cells. Our results demonstrate the potential application of this library in biosensors, bio-imaging and pH indicators.
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Cite this article as:
Cheol Hong Seong, P. Murale Dhiraj and Lee Jun-Seok, Combinatorial Dansyl Library and its Applications to pH-Responsive Probes, Combinatorial Chemistry & High Throughput Screening 2016; 19 (5) . https://dx.doi.org/10.2174/1386207319666160408150203
DOI https://dx.doi.org/10.2174/1386207319666160408150203 |
Print ISSN 1386-2073 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5402 |
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