摘要
金属在人体生理中起着重要的作用。铜和锌是密切相关的微量元素,参与细胞增殖、生长、基因表达、凋亡等过程。他们的平衡是至关重要的,并由一个资源丰富的系统严格控制与此同时它们可以运输蛋白,提供铜和锌离子的目标靶点。一些恶性肿瘤的发现,或者在头部和颈部癌症可以得出锌铜的平衡异常。癌症患者血清或组织中铜、锌离子的升高或降低可以观察到这种平衡失衡。在头颈部癌中,这些水平的改变与其他恶性肿瘤相比异常明显,这使他们成为研究的对象,因此,锌和铜离子可能是进一步研究的头部和颈部癌症的发展和进展一个很好的目标。本综述的目的是总结铜和锌的生理作用、结合和运输机制,并基于这些研究,来探索它在头部和颈部癌症的角色。为了提供有力的证据,用Meta分析方法来分析失调的水平。
关键词: 锌、铜、血浆铜蓝蛋白、金属硫蛋白、癌、头颈部肿瘤、金属组学,荟萃分析。
Current Medicinal Chemistry
Title:Zinc and Copper Homeostasis in Head and Neck Cancer: Review and Meta-Analysis
Volume: 23 Issue: 13
Author(s): Alzbeta Ressnerova, Martina Raudenska, Monika Holubova, Marketa Svobodova, Hana Polanska, Petr Babula, Michal Masarik and Jaromir Gumulec
Affiliation:
关键词: 锌、铜、血浆铜蓝蛋白、金属硫蛋白、癌、头颈部肿瘤、金属组学,荟萃分析。
摘要: Metals are known for playing essential roles in human physiology. Copper and zinc are trace elements closely dependent on one another and are involved in cell proliferation, growth, gene expression, apoptosis and other processes. Their homeostasis is crucial and tightly controlled by a resourceful system of transporters and transport proteins which deliver copper and zinc ions to their target sites. Abnormal zinc and copper homeostasis can be seen in a number of malignancies and also in head and neck cancer. Imbalance in this homeostasis is observed as an elevation or decrease of copper and zinc ions in serum or tissue levels in patients with cancer. In head and neck cancer these altered levels stand out from those of other malignancies which makes them an object of interest and therefore zinc and copper ions might be a good target for further research of head and neck cancer development and progression. This review aims to summarize the physiological roles of copper and zinc, its binding and transport mechanisms, and based on those, its role in head and neck cancer. To provide stronger evidence, dysregulation of levels is analysed by a meta-analytical approach.
Export Options
About this article
Cite this article as:
Alzbeta Ressnerova, Martina Raudenska, Monika Holubova, Marketa Svobodova, Hana Polanska, Petr Babula, Michal Masarik and Jaromir Gumulec , Zinc and Copper Homeostasis in Head and Neck Cancer: Review and Meta-Analysis, Current Medicinal Chemistry 2016; 23 (13) . https://dx.doi.org/10.2174/0929867323666160405111543
DOI https://dx.doi.org/10.2174/0929867323666160405111543 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
A Review on Extraction, Synthesis and Anticancer Activity of Betulinic Acid
Current Bioactive Compounds Invariant Natural Killer T Cell-Based Therapy of Autoimmune Diseases
Current Immunology Reviews (Discontinued) Natural Products and their (Semi-)Synthetic Forms in the Treatment of Migraine: History and Current Status
Current Medicinal Chemistry Transactivation of EGFR by G Protein-Coupled Receptor in the Pathophysiology of Intimal Hyperplasia
Current Vascular Pharmacology Drug Therapy of Neuropathic Pain: Current Developments and Future Perspectives
Current Drug Targets HER3 and its Ligand, Heregulin, as Targets for Cancer Therapy
Recent Patents on Anti-Cancer Drug Discovery Histone Deacetylase Inhibitors: A New Wave of Molecular Targeted Anticancer Agents
Recent Patents on Anti-Cancer Drug Discovery Benzo[a]pyrene Toxicity and Inflammatory Disease
Current Rheumatology Reviews Radionuclide Molecular Imaging Using Affibody Molecules
Current Pharmaceutical Biotechnology An Evaluation of the Antioxidant and Anticancer Properties of Complex Compounds of Copper (II), Platinum (II), Palladium (II) and Ruthenium (III) for Use in Cancer Therapy
Mini-Reviews in Medicinal Chemistry Tyrosine Kinase Blockers: New Hope for Successful Cancer Therapy
Anti-Cancer Agents in Medicinal Chemistry Natural Killer Cells Preferentially Target Cancer Stem Cells; Role of Monocytes in Protection Against NK Cell Mediated Lysis of Cancer Stem Cells
Current Drug Delivery Viral Disorder or Disordered Viruses: Do Viral Proteins Possess Unique Features?
Protein & Peptide Letters PET-Evaluated Transport of [11C]Hydroxyurea Across the Rat Blood-Brain Barrier - Lack of Influence of Cyclosporin and Probenecid
Drug Metabolism Letters The Role of Tregs in Cancer: Foxp3 as a Putative Target for Therapy
Current Signal Transduction Therapy Cardiac Morbidity in an HIV-1 Lipodystrophy Patient Cohort Expressing the TNF-α-238 G/A Single Nucleotide Gene Polymorphism
Current HIV Research Modulation of Matrix Metalloproteinases by Plant-derived Products
Current Cancer Drug Targets Exploiting Internal Ribosome Entry Sites in Gene Therapy Vector Design
Current Gene Therapy Role of Metabolic Enzymes P450 (CYP) on Activating Procarcinogen and their Polymorphisms on the Risk of Cancers
Current Drug Metabolism Translational Research in Oncology: The Need of Additional In Vitro Preclinical Testing Methods for New Drugs
Current Pharmaceutical Design