在癌症治疗中智能药物输送系统

Title:Smart Drug Delivery Systems in Cancer Therapy

Volume: 19 Issue: 3

关键词: 智能药物递送，刺激响应药物释放，纳米载体，靶向药物递送，智能纳米载体，靶向癌症治疗

摘要: Background: Smart nanocarriers have been designed for tissue-specific targeted drug delivery, sustained or triggered drug release and co-delivery of synergistic drug combinations to develop safer and more efficient therapeutics.

Objective: Advances in drug delivery systems provide reduced side effects, longer circulation half-life and improved pharmacokinetics.

Results: Smart drug delivery systems have been achieved successfully in the case of cancer. These nanocarriers can serve as an intelligent system by considering the differences of tumor microenvironment from healthy tissue, such as low pH, low oxygen level, or high enzymatic activity of matrix metalloproteinases.

Conclusion: The performance of anti-cancer agents used in cancer diagnosis and therapy is improved by enhanced cellular internalization of smart nanocarriers and controlled drug release. Here, we review targeting, cellular internalization; controlled drug release and toxicity of smart drug delivery systems. We are also emphasizing the stimulus responsive controlled drug release from smart nanocarriers.

Cite this article as:

Smart Drug Delivery Systems in Cancer Therapy, Current Drug Targets 2018; 19 (3) . https://dx.doi.org/10.2174/1389450117666160401124624