摘要
背景:急性心肌梗死的实验研究显示,最终梗死面积的一半可能是由于再灌注损伤而不是初始缺血事件。近三十年的研究加深了我们对缺血再灌注损伤的分子机制的认识,并探讨了减少再灌注损伤发生率和严重程度的几种治疗策略。 目的:探讨减轻心肌再灌注损伤方法的有希望的治疗方法和未来展望。 结果:解决再灌注的现有疗法可分为包括非药物和药物干预措施的两个主要组。已经采用无数药理和非药物方法来减少致死性再灌注损伤。尽管许多初步临床研究是阴性的,但更近期的概念验证临床试验是有希望的。迄今为止,最令人鼓舞的结果是缺血后处理,远端缺血预处理,ANP,腺苷,环孢素和艾塞那肽。 结论:研究表明,非药物和药理学调理可以一起使用,作为改善缺血性心脏病患者临床疗效的多方面方法的一部分。
关键词: 心肌梗死,心肌再灌注损伤,缺血调理,心脏药理学,临床试验。
图形摘要
Current Drug Targets
Title:Progress in Therapies for Myocardial Ischemia Reperfusion Injury
Volume: 18 Issue: 15
关键词: 心肌梗死,心肌再灌注损伤,缺血调理,心脏药理学,临床试验。
摘要: Background: Experimental studies of acute myocardial infarction have revealed that up to half of the final infarct size may be due to reperfusion injury rather than the initial ischemic incident. Research over the past three decades has deepened our understanding of the molecular mechanisms underlying ischemic reperfusion injury and several therapeutic strategies to decrease the incidence and severity of reperfusion injury have been explored.
Objective: To discuss the promising therapies and future perspectives on methods to attenuate myocardial reperfusion injury.
Results: Existing therapies that address reperfusion can be divided into two major groups comprising nonpharmacological and pharmacological interventions. Myriad pharmacological and nonpharmacological approaches to reduce lethal reperfusion injury have been employed. Although many initial clinical studies were negative, more recent proof-of-concept clinical trials are promising. To date, the most encouraging results are with ischemic postconditioning, remote ischemic preconditioning, ANP, adenosine, cyclosporine and exenatide.
Conclusion: Studies demonstrate that nonpharmacological and pharmacological conditioning can be used together as part of a multifaceted approach to improve clinical outcomes in patients with ischemic heart disease.
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Cite this article as:
Progress in Therapies for Myocardial Ischemia Reperfusion Injury, Current Drug Targets 2017; 18 (15) . https://dx.doi.org/10.2174/1389450117666160401120308
DOI https://dx.doi.org/10.2174/1389450117666160401120308 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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