Abstract
In this non-comprehensive review a selection of tandem processes combining sigmatropic rearrangement with Diels–Alder reactions is presented. The synthetic utility of these two transformations is indisputable as they can lead to complex natural products in an efficient and selective way. Most of the examples presented here have been chosen in view of their application to natural products synthesis. The emphasis of the discussion is put on the illustration of new strategic disconnections becoming accessible thanks to tandem processes.
Keywords: Diels–Alder, cycloaddition, sigmatropic rearrangements, tandem cascade, tactical combination, retrosynthesis.
Graphical Abstract
Current Organic Chemistry
Title:Applications of Tandem Diels–Alder/Sigmatropic Rearrangement Reactions to Natural Product Synthesis
Volume: 20 Issue: 22
Author(s): Reinhard Neier and Ewa Banach
Affiliation:
Keywords: Diels–Alder, cycloaddition, sigmatropic rearrangements, tandem cascade, tactical combination, retrosynthesis.
Abstract: In this non-comprehensive review a selection of tandem processes combining sigmatropic rearrangement with Diels–Alder reactions is presented. The synthetic utility of these two transformations is indisputable as they can lead to complex natural products in an efficient and selective way. Most of the examples presented here have been chosen in view of their application to natural products synthesis. The emphasis of the discussion is put on the illustration of new strategic disconnections becoming accessible thanks to tandem processes.
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Cite this article as:
Neier Reinhard and Banach Ewa, Applications of Tandem Diels–Alder/Sigmatropic Rearrangement Reactions to Natural Product Synthesis, Current Organic Chemistry 2016; 20 (22) . https://dx.doi.org/10.2174/1385272820666160331234505
DOI https://dx.doi.org/10.2174/1385272820666160331234505 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
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