左前糖代谢和非淀粉样-β负荷预测阿尔茨海默病中命名障碍

Title:Left Anterior Temporal Glucose Metabolism and not Amyloid-beta Load Predicts Naming Impairment in Alzheimer’s Disease

Volume: 13 Issue: 6

Author(s): Lars Frings, Timo S. Spehl, Michael Hüll, Philipp T. Meyer

Affiliation:

关键词: 阿尔茨海默病，淀粉样蛋白，对抗命名，匹兹堡化合物，正电子发射断层扫描。

摘要: Naming impairment in Alzheimer’s disease dementia (AD) is associated with atrophy of the left anterior temporal lobe (ATL). We aimed to elucidate if regional cerebral glucose metabolism, as a biomarker of synaptic dysfunction and neurodegeneration, of the left ATL predicts naming impairment, and if amyloid-beta (Aβ) deposition, a pathological hallmark of AD, contributes to the prediction.

Twenty-nine patients with AD underwent combined [¹¹C]PIB and [¹⁸F]FDG PET examinations for assessment of Aβ load and regional cerebral glucose metabolism. An a priori defined region of interest was used for regional PET analyses of the left ATL. In linear stepwise regression analyses, glucose metabolism of the left ATL was the only significant predictor of naming performance, independent of sex, age, and education. Neither regional nor global Aβ load contributed to the prediction.

Left ATL glucose metabolism predicts naming impairment in AD. By contrast, Aβ deposition does not predict naming impairment.

Cite this article as:

Lars Frings, Timo S. Spehl, Michael Hüll, Philipp T. Meyer , Left Anterior Temporal Glucose Metabolism and not Amyloid-beta Load Predicts Naming Impairment in Alzheimer’s Disease, Current Alzheimer Research 2016; 13 (6) . https://dx.doi.org/10.2174/1567205013666160322141955